Mechanistic
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Fibrinogen Depletion in PDAC: Clarifying the Mechanistic Chain and the Metastatic Step(s) Affected
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We read with great interest the article by Chowdhury et al,1 who report that lowering liver-derived fibrinogen using clinically translatable platforms ...

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Electroacupuncture for Postoperative Ileus: Critical Gaps in Mechanistic Validation and Clinical Relevance
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I commend Pei et al1 for their rigorous multicenter trial evaluating electroacupuncture (EA) in reducing postoperative ileus (POI) after laparoscopic ...

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Mechanistic Gaps and Therapeutic Promise in MASH-ATM sEV Research
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Rohm et al1 propose a novel model linking adipose tissue macrophage (ATM)–derived small extracellular vesicles (sEVs) to liver fibrosis via ...

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Comments on Statistical and Mechanistic Aspects of Perforin and CXCL9 in IBD-Induced Depression
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We read with great interest the recent article by Hart et al1 titled “Perforin Generated by CD8+ T Cells Exacerbates Inflammatory Bowel Disease–Induced ...

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