Serotonin (5-hydroxytryptamine; 5-HT) is a key regulator of gastrointestinal function and exerts its effects through a diversity of 5-HT receptors. In the gut, 5-HT is released primarily by enterochromaffin cells, which act as specialized epithelial chemo- and mechanosensors. In humans, 5-HT modulates gastric sensorimotor function, and animal studies suggest that it is involved in enteric neurogenesis. Altered serotonergic signalling is increasingly recognized as an important contributor to the pathophysiology of gastric motility disorders and therefore represents an important therapeutic target.
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