Pancreatic
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Multiple Pancreatic Masses in a Young Woman: What Are We Really Treating?
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Question: An 18-year-old woman presented with persistent left upper quadrant abdominal pain for more than 1 month, associated with weight loss. She had no ...

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Inflammation-Induced Claudin-2 Up-Regulation Limits Pancreatitis Development by Enhancing Pancreatic Ductal Transport
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Up-regulation of the claudin-2 protein helps protect the pancreas during inflammation by enhancing fluid transport, which may offer new treatment strategies ...

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Chemotherapy-Induced Remodeling Versus Clonal Selection in CD276-Driven Basal-Like Chemoresistance in Pancreatic Cancer
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We read with great interest the elegant single-cell study by Zhang et al1 describing chemotherapy-induced remodeling in pancreatic ductal adenocarcinoma ...

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Targeting Oncomucin-driven Immunosuppression Improves the Efficacy of K-rasG12D Inhibition in Pancreatic Cancer
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Pancreatic cancer expresses multiple oncogenic mucins as a shield to reinforce cancer-sustaining signals and immunosuppression, making treatments ...

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Epithelial FOXP3 Orchestrates O-Glycosylated IL6 Secretion to Drive Pancreatic Fibrocarcinogenesis
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A rare population of FOXP3-positive pancreatic epithelial cells functions as “trigger cells” that secrete O-glycosylated IL6, initiating a self-amplifying ...

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A Clinical Perspective on Comparative Models of Pancreatic Cyst Surveillance
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We read with interest the analysis by White et al1 comparing the 2015 American Gastroenterological Association (AGA),2 2017 Fukuoka,3 and 2024 Kyoto4 ...

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Targeting Mutual Dependence of Phosphatidylinositol-3-Kinase α/δ and Small Ubiquitin-Like Modifier Signaling in Pancreatic Cancer
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Blocking phosphatidylinositol-3-kinase and small ubiquitin-like modifier pathways together kills pancreatic cancer cells and leads to an immune-assisted ...

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Validation of a Serum-Based Biomarker Signature for Detection of Early-Stage Pancreatic Ductal Adenocarcinoma
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A panel of 5 biomarkers performed well at detecting early-stage pancreatic cancer in individuals with stage I and II pancreatic tumors and in cancer-free ...

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The Role of Alcohol in Pancreatic Diseases: A Comprehensive Perspective
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Alcohol abuse is a leading cause of global health care concerns and can cause health loss, disease, and death. In addition to the liver, the pancreas is a ...

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