Integrating Static and Dynamic Models to Predict Cannabidiol-Mediated Metabolic Drug-Drug Interactions
CannaSearch Daily |
Cannabidiol (CBD) inhibits multiple cytochrome P450 (CYP450) enzymes in vitro via reversible and time-dependent mechanisms, raising concerns for metabolic drug-drug interactions (DDIs). Clinical DDI data for CBD are limited, and the translation of in vitro derived inhibition parameters into in vivo DDI predictions remains uncertain. We implemented a stepwise, model-informed framework to evaluate CBD-mediated metabolic DDIs using (i) basic, (ii) mechanistic static (MSM), and (iii) physiologically…
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