{"id":7025285,"date":"2026-08-03T15:50:16","date_gmt":"2026-08-03T15:50:16","guid":{"rendered":"https:\/\/peraltafinancing.com\/agriculture\/micropep-starts-regulatory-process-of-peptide-based-biofungicide\/"},"modified":"2026-08-03T15:50:16","modified_gmt":"2026-08-03T15:50:16","slug":"micropep-starts-regulatory-process-of-peptide-based-biofungicide","status":"publish","type":"post","link":"https:\/\/fivemor.com\/?p=7025285","title":{"rendered":"Micropep starts regulatory process of peptide-based biofungicide"},"content":{"rendered":"<p> <br \/>\n<\/p>\n<div>\n<p>France- and US-based ag biotech company <a href=\"https:\/\/micro-pep.com\/\">Micropep<\/a> is closer to commercializing its peptide-based biofungicide Promisin after making regulatory submissions in the United States and the European Union this week.<\/p>\n<p>The submissions come on the heels of Promisin submissions in Paraguay and Brazil, and send \u201can important signal to external stakeholders,\u201d says Micropep VP of regulatory Dr. Kevin Leiner.<\/p>\n<p><span style=\"font-size: 1.125rem;\">\u201cIt\u2019s a really strong proof point for the capabilities of Micropep and for the ability of our Krisalix discovery platform to advance interesting product candidates and de-risk them to the point where we can get them on the market and provide a valuable tool to the farmer.\u201d<\/span><\/p>\n<p>Promisin is the first product to come out of Krisalix, the company\u2019s AI-based discovery platform platform, which uses computational biology, AI, and formulation science to discover the best micro-peptide sequences for crop protection.<\/p>\n<p>According to Leiner, regulatory submissions for the product also mark the company\u2019s shift from a research and discovery entity to one truly readying itself for launch in commercial markets.<\/p>\n<h4><strong>Fighting fungicide resistance with peptides<\/strong><\/h4>\n<p>Promisin relies on a novel biological mode of action to fight fungal diseases in crops, and is designed to complement existing fungicide tools rather than replace them outright, says Leiner. It is particularly useful in managing fungicide resistance, which has <a href=\"https:\/\/apsjournals.apsnet.org\/doi\/10.1094\/PHYTO-10-22-0370-KD\">steadily risen since the 1970s<\/a>.<\/p>\n<p>The bulk of conventional fungicides are site-specific, meaning they target one single metabolic pathway. A single genetic mutation in that pathway, such as one amino acid in the protein, <a href=\"https:\/\/www.extension.purdue.edu\/extmedia\/bp\/bp-71-w.pdf\">can reduce a fungus\u2019s sensitivity<\/a> to a chemical and render it ineffective.<\/p>\n<p>Promisin is in a class of peptides that acts by disrupting cell membranes rather than binding to a specific target, says Leiner. Because of that,\u00a0<span style=\"font-size: 1.125rem;\">\u201cIt would be very difficult for an organism to evolve resistance to Promisin peptides.\u201d<\/span><\/p>\n<p>This class of peptides also complements existing pest management strategies, he adds. Promisin mixes well with other solutions in the tank, allowing farmers to hit targets with multiple modes of action, which also addresses and lessen the chance of resistance developing.<\/p>\n<p>\u201c[For] what is lost against a conventional fungicide. Promisin can come in and and essentially clean up the resistant strains.\u201d<\/p>\n<p>Outside of resistance management, Promisin has already shown strong efficacy in hundreds of field trials around the world over multiple years, says Leiner, who adds that there is a \u201chighly favorable safety and sustainability profile\u201d in play too.<\/p>\n<p>\u201cWe don\u2019t see significant concern with non-target organisms. From a human and environmental safety perspective, it\u2019s fantastic. From a sustainability perspective, we\u2019re not worried about persistence in the environment, the way you may be with some small molecule conventional pesticides. We\u2019re not worried about residues or having to establish tolerances or maximum residue limits.\u201d<\/p>\n<h4><strong>Towards commercialization\u00a0<\/strong><\/h4>\n<p>Leiner joined Micropep a few years ago, when it was essentially a discovery and research company \u201cwith an almost academic feel.\u201d<\/p>\n<p><span style=\"font-size: 1.125rem;\">\u201cThese regulatory submissions really are the the milestone where we can say, okay, this development stage for the initial crops is now complete. Now we start our pre-commercial phase.\u201d<\/span><\/p>\n<p>Soybeans are a key export in Paraguay and Brazil, and Micropep will focus on that and other row crops for those markets. In particular, it is targeting <em>Phakopsora pachyrhizi<\/em> (Asian soybean rust), <em>Corynespora cassiicola<\/em> (Target Spot), and <em>Cercospora kikuchii<\/em> (Leaf Blight).<\/p>\n<p>Row crops will also be a focus area in the US along with grapevines and potatoes. In Europe, which produces significantly fewer soybeans, Micropep will work mostly in grapevines and potatoes.<\/p>\n<p>Last year saw Micropep <a href=\"https:\/\/micro-pep.com\/micropep-media\/newceo\/\">appoint new CEO<\/a> Georg Goeres, who previously ran the biologicals unit of Indigo Ag and will lead Micropep\u2019s efforts to commercialization.<\/p>\n<p>Regulatory evaluations and approvals for Promisin will vary in terms of timeline based on the region. Brazil, for example, has <a href=\"https:\/\/agfundernews.com\/biogeographical-context-is-key-to-accelerating-rd-in-biologicals-says-brazil-cdmo-ideelab\">a notably faster approval timeline<\/a> than the European Union\u2014around 18 months versus a few years, respectively.<\/p>\n<p>In the meantime, Micropep will \u201cprepare the ground\u201d for product launches, says Leiner. \u201cWe will\u00a0make sure the supply chain is established, distribution relationships are established, and that way, when we have the market authorizations in each country, we\u2019ll be ready to hit the ground running.\u201d<\/p>\n<p>The company will continue to work on fungicides but will also look for new peptides that could work as herbicides and insecticides.<\/p>\n<\/p><\/div>\n\n","protected":false},"excerpt":{"rendered":"<p>France- and US-based ag biotech company Micropep is closer to commercializing its peptide-based biofungicide Promisin after making regulatory submissions in the United States and the European Union this week. The submissions come on the heels of Promisin submissions in Paraguay and Brazil, and send \u201can important signal to external stakeholders,\u201d says Micropep VP of regulatory [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":7025286,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[12026],"tags":[188915,188913,188914,13306,15894,15984],"dealstore":[],"offerexpiration":[],"class_list":["post-7025285","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-agriculture","tag-biofungicide","tag-micropep","tag-peptidebased","tag-process","tag-regulatory","tag-starts"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.4 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Micropep starts regulatory process of peptide-based biofungicide - Som2ny Network<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/fivemor.com\/?p=7025285\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Micropep starts regulatory process of peptide-based biofungicide - Som2ny Network\" \/>\n<meta property=\"og:description\" content=\"France- and US-based ag biotech company Micropep is closer to commercializing its peptide-based biofungicide Promisin after making regulatory submissions in the United States and the European Union this week. 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