{"id":63357,"date":"2025-02-02T01:55:12","date_gmt":"2025-02-02T01:55:12","guid":{"rendered":"https:\/\/peraltafinancing.com\/agriculture\/biomilq-files-for-bankruptcy-amid-devastating-ip-dispute\/"},"modified":"2025-02-02T01:55:12","modified_gmt":"2025-02-02T01:55:12","slug":"biomilq-files-for-bankruptcy-amid-devastating-ip-dispute","status":"publish","type":"post","link":"https:\/\/fivemor.com\/?p=63357","title":{"rendered":"BIOMILQ files for bankruptcy amid ‘devastating’ IP dispute"},"content":{"rendered":"


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BIOMILQ<\/a>\u2014a startup culturing mammary cells to produce bioactives found in breastmilk\u2014has filed for bankruptcy amid a protracted IP dispute with the ex-husband of one of the cofounders that she says rendered the firm \u201cuninvestable and unacquirable.\u201d<\/p>\n

Founded in 2020 by cell biologist Dr. Leila Strickland and food scientist Michelle Egger, North Carolina-based BIOMILQ originally planned to produce cell-cultured human milk in bioreactors full of \u201clactating\u201d mammary epithelial cells. It later pivoted to using the cells as mini-biofactories to produce high-value bioactives found in breastmilk such as human milk oligosaccharides, osteopontin, and exosomes.<\/p>\n

The firm, which has raised $24.5 million from investors including multiple billionaire-backed Breakthrough Energy Ventures<\/a> and Novo Holdings<\/a>, has developed cell lines that can produce a wide range of human milk oligosaccharides in a scalable system, claims Strickland, who took over as CEO in March 2023 following Egger\u2019s departure.<\/p>\n

However, a legal dispute with her ex-husband (Shayne Guiliano at 108Labs<\/a>) over IP has effectively prevented the company from raising money or finding a buyer, she told AgFunderNews<\/em>.<\/p>\n

\u201cThe decision to file Chapter 7 comes after a long\u00a0legal dispute that has haunted the company since its founding. My former husband has asserted marital, fiduciary, and inventorship interests in BIOMILQ IP through a complex series of cases in district and state, and federal courts.\u201d<\/p>\n

\u2018We have no choice other than to take the final steps to shut down the company\u2019<\/strong><\/h4>\n

The legal spat between the two heated up in early 2022 when BIOMILQ accused* Guiliano of stealing trade secrets in a complaint that describes him entering Dr Strickland\u2019s home without her knowledge or permission and photographing pages from a BIOMILQ notebook.<\/p>\n

Guiliano, in turn, has argued in publicly-available court filings** that he should be listed as a co-inventor on foundational patents assigned to BIOMILQ based on IP he says he developed with Strickland between 2013 and 2020 while they were both working at 108Labs.<\/p>\n

He has also argued that IP assigned to BIOMILQ should have been assigned to 108Labs and asserted marital rights to assets including IP that was developed at BIOMILQ well after the couple split. As such claims could potentially impact the entire IP portfolio, this has deterred potential investors and acquirers, said Strickland.<\/p>\n

Intellectual property can be treated as marital property to the extent that it has any demonstrable value. And when a marriage dissolves, it is divided with the marital estate. Strickland says that she and Guiliano finalized their divorce in 2023, but their marital estate remains locked in a civil proceeding because of the dispute about BIOMILQ\u2019s IP. In court filings, Guiliano asserts that \u201cSpouses owe to one another a mutual obligation to manage, control and preserve their community assets with the utmost care and loyalty. Strickland breached her marital obligations in her dealings with BIOMILQ.\u201d<\/p>\n

According to a recent court filing from Guiliano, \u201cBut for its misappropriation of Guiliano, Strickland, and 108Labs\u2019 proprietary technology, BIOMILQ would never have existed as a viable company.\u201d BIOMILQ in turn claimed that his request for inventorship correction \u201cfails to identify with sufficient particularity any claim elements of BIOMILQ\u2019s patents that Mr. Guiliano purports to have contributed to or conceived.\u201d<\/p>\n

While several of Guiliano\u2019s legal claims against BIOMILQ and other parties have been dismissed or voluntarily withdrawn, the litigation is ongoing and has \u201chad the effect of simultaneously shortening our runway while making us uninvestable and unacquirable,\u201d claimed Strickland. Despite an \u201cexhaustive effort\u201d to raise funds throughout 2024, BIOMILQ was unable to close its round.<\/p>\n

Strickland added: \u201cWe had so much enthusiasm from investors who all wanted us to get past this. We had a likely lead identified but they understandably couldn\u2019t proceed while this was going on. By the end of the summer, I started talking to a number of candidates who might want to acquire the technology but of course we ran into the same issues.\u201d<\/p>\n

According to Strickland, \u201cWe finally went into a 12-hour mediation session in December that didn\u2019t resolve this and we have had no choice other than to take the final steps to shut down the company.\u201d<\/p>\n

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\u201cWith regard to securing capital for ongoing operations, Mr. Guiliano\u2019s conduct is impeding BIOMILQ\u2019s ongoing (and crucial) efforts to find new
investors and raise additional funds from existing investors. Raising capital in the current high-interest rate environment is challenging under the best of circumstances but is particularly difficult when a substantial portion of BIOMILQ\u2019s capital must be diverted to this litigation where Mr. Guiliano\u2019s persistent abuse of the judicial process has impeded a reasonable path to resolution.\u201d Affidavit from Dr. Christine Ring, independent board member, BIOMILQ, July 2024<\/strong><\/p>\n<\/blockquote>\n

Asked to comment on the litigation, Guiliano told AgFunderNews: \u201c<\/em>I think the public record probably speaks for itself.\u201d<\/p>\n

Asked to comment on Dr. Ring\u2019s statement regarding the impact of the litigation on the viability of the company, Guiliano\u2019s lead counsel in that action, James C. White at J.C. White Law Group, said: \u201cWe believe that Shayne\u2019s \u2018conduct\u2019 consists of asserting valid claims regarding his rights. We stand by the claims in the pleading.\u201d<\/p>\n

\u2018A devastating ending\u2019<\/strong><\/h4>\n

Strickland added: \u201cThis is a particularly devastating ending as our progress last year was off the charts. Beyond the HMO program, we created an unprecedented collection of mammary cell lines and a raft of patents related to just a few of the things you could do with them. The fate of these assets is uncertain, but my hope is that they will be made available in a public sale in the Chapter 7 process.\u201d<\/p>\n

With the Chapter 7 filing, Strickland and BIOMILQ\u2019s board of directors have now been discharged. The company\u2019s affairs have been turned over to a court-appointed trustee and the pending litigation against the company has been stayed while the bankruptcy process plays out. Strickland said that the complexity of the situation makes it difficult to predict how things will unfold, but she hopes that the process will move quickly to establish a free-and-clear title to the assets that were developed at BIOMILQ.<\/p>\n

She added: \u201cOur portfolio represents $24.5 million of investment, poured into the smartest people I\u2019ve ever met, who made incredible progress on important challenges. I\u2019d like to generate awareness about what we did among potential buyers so that if the technology does get sold, it will have the best chance possible of being picked up by teams that will do amazing things with it.\u201d<\/p>\n

BIOMILQ\u2019s IP<\/strong><\/h4>\n

Strickland says that BIOMILQ has some granted patents and some pending patents reflecting the firm\u2019s early IP, plus more recent pending patents covering cell line development methods to get mammary epithelial cells to make high-value bioactives including human milk oligosaccharides (HMOs), proteins such as osteopontin, and exosomes. Another patent application covers a scalable bioprocess to grow cells in suspension in perfusion bioreactors, which opens the door to scaling these applications..<\/p>\n

According to Strickland, the HMO program is the best example of the platform\u2019s potential. While some companies are using precision fermentation to produce select HMOs such as 2\u2019-FL for the infant formula market, she says, microbes are poorly equipped to make many of the bioactives in breastmilk.<\/p>\n

BIOMILQ\u2019s mammary cell lines, however, can produce scores of HMOs \u201cincluding branched and elongated structures that have evidence of functional and clinical benefits\u201d but currently lack a scalable method of production.<\/p>\n

\u201cThere are 200 oligosaccharides in human milk, only a few of which you can make with bacteria and other microbes. We can make dozens of HMOs that are long, branched complex structures, not the simple three and four unit structures that currently can be made with microbes. As an example we\u2019ve seen evidence that our cells can make [the HMO] DSLNT, which helps protect low birth weight babies from a serious intestinal condition called necrotizing enterocolitis. Right now, there are no approved treatments for necrotizing enterocolitis, and no established manufacturing methods to make DSLNT, but our cells can make it.<\/p>\n

\u201cWe have IP filed around the pathway engineering and other work on how you control the biosynthetic output so that the cells are putting all of their energy towards making as much of these HMOs as possible, so we get higher titers.\u201d<\/p>\n

Strickland believes that had BIOMILQ been able to continue its work, it would have been able to achieve kilogram-scale production of complex HMOs: \u201cOne version of my pitch last year was about raising money to prove out our manufacturing method, which would unlock the clinical development of a life-saving solution for premature infants.\u201d The cells that her team engineered to do this are currently in cryogenic storage and facing an \u201cuncertain fate,\u201d she noted.<\/p>\n

\u201cI don\u2019t know where our technology will end up, but through this experience I\u2019ve realized that the loss of innovation to IP litigation is upsettingly common. BIOMILQ\u2019s circumstances may be unique, but the fact that my company was snuffed out by a weaponized legal process is a systemic issue that threatens all
innovators, and I think it\u2019s important to raise awareness about this topic.\u201d<\/p>\n

*BIOMILQ INC v Shayne Guiliano and 108Labs LLC. Case No. 22-CVS-000255<\/p>\n

**Shayne Guiliano and 108Labs LLC v Leila Strickland and BIOMILQ INC. Case No. 1:24-cv-00563<\/p>\n<\/p><\/div>\n\n","protected":false},"excerpt":{"rendered":"

BIOMILQ\u2014a startup culturing mammary cells to produce bioactives found in breastmilk\u2014has filed for bankruptcy amid a protracted IP dispute with the ex-husband of one of the cofounders that she says rendered the firm \u201cuninvestable and unacquirable.\u201d Founded in 2020 by cell biologist Dr. Leila Strickland and food scientist Michelle Egger, North Carolina-based BIOMILQ originally planned […]<\/p>\n","protected":false},"author":1,"featured_media":63358,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[12026],"tags":[11433,34613,34611,17577,16868,8277,34612],"dealstore":[],"offerexpiration":[],"class_list":["post-63357","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-agriculture","tag-bankruptcy","tag-biomilq","tag-cellular-agriculture","tag-devastating","tag-dispute","tag-files","tag-frankly-speaking"],"yoast_head":"\nBIOMILQ files for bankruptcy amid 'devastating' IP dispute - 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