{"id":364444,"date":"2026-08-03T01:03:01","date_gmt":"2026-08-03T01:03:01","guid":{"rendered":"https:\/\/peraltafinancing.com\/uncategorized\/the-relationship-between-endocannabinoids-the-microbiome-and-melanoma\/"},"modified":"2026-08-03T01:03:01","modified_gmt":"2026-08-03T01:03:01","slug":"the-relationship-between-endocannabinoids-the-microbiome-and-melanoma","status":"publish","type":"post","link":"https:\/\/fivemor.com\/?p=364444","title":{"rendered":"The Relationship Between (Endo)cannabinoids, the Microbiome and Melanoma"},"content":{"rendered":"<p> <br \/>\n<\/p>\n<div id=\"article-page\" data-article-pmid=\"42538621\" wp_automatic_readability=\"46.384968102073\">\n<p>    <main class=\"article-details\" id=\"article-details\" wp_automatic_readability=\"44.595299551691\"><\/p>\n<p><!-- \"Filters applied\" shows only when page is redirected from search --><br \/>\n<!-- because search found one result --><\/p>\n<header class=\"heading\" id=\"heading\" wp_automatic_readability=\"0.8225371120108\">\n<div class=\"full-view\" id=\"full-view-heading\">\n<div class=\"article-citation\">\n<p>Review<\/p>\n<p>      <span class=\"citation-doi\"><br \/>\n        doi: 10.1002\/prp2.70304.<br \/>\n      <\/span><\/p><\/div>\n<p>    Affiliations<\/p>\n<p>    <button class=\"more-details\" id=\"toggle-authors\" data-alt-text=\"Collapse\" aria-controls=\"expanded-authors\" aria-expanded=\"false\" data-pinger-ignore=\"\" data-fetch-url=\"\/42538621\/long-authors\/\" data-id-prefix=\"\"><br \/>\n      <span class=\"title\"><br \/>\n        Expand<br \/>\n      <\/span><br \/>\n    <\/button><\/p>\n<div class=\"extended-article-details\" id=\"expanded-authors\" aria-hidden=\"true\">\n<div class=\"expanded-authors\" id=\"full-view-expanded-authors\">\n<div class=\"affiliations\">\n<h3 class=\"title\">\n            Affiliations<br \/>\n          <\/h3>\n<ul class=\"item-list\">\n<li data-affiliation-id=\"full-view-affiliation-1\" id=\"full-view-affiliation-1\"><sup class=\"key\">1<\/sup> Department of Pharmacy, School of Applied Sciences, University of Huddersfield, Huddersfield, UK.<\/li>\n<li data-affiliation-id=\"full-view-affiliation-2\" id=\"full-view-affiliation-2\"><sup class=\"key\">2<\/sup> Clinic for Tumors, Clinical Hospital Centre Rijeka, Rijeka, Croatia.<\/li>\n<li data-affiliation-id=\"full-view-affiliation-3\" id=\"full-view-affiliation-3\"><sup class=\"key\">3<\/sup> Department of Basic and Clinical Pharmacology With Toxicology, Faculty of Medicine, University of Rijeka, Rijeka, Croatia.<\/li>\n<\/ul><\/div>\n<\/p><\/div>\n<\/p><\/div>\n<p>\n  Item in Clipboard\n<\/p>\n<\/p><\/div>\n<div class=\"short-view\" id=\"short-view-heading\" wp_automatic_readability=\"5.9377431906615\">\n<p>Review<\/p>\n<p>\n  <span class=\"authors-list\"><\/p>\n<p>        <span class=\"authors-list-item \"><span class=\"full-name\">Farideh A Javid<\/span><span class=\"citation-separator\">\u00a0et al.<\/span><\/span><\/p>\n<p>  <\/span><\/p>\n<p>      <span class=\"citation-journal\"><br \/>\n        Pharmacol Res Perspect<span class=\"citation-separator\">.<\/span><br \/>\n      <\/span><\/p>\n<p>        <span class=\"date\"><br \/>\n          <span class=\"citation-year\">2026 Aug<\/span><span class=\"citation-separator\">.<\/span><br \/>\n        <\/span><\/p>\n<div class=\"more-article-details-section with-display-settings\">\n          <button class=\"more-article-details\" id=\"toggle-article-details\" data-alt-text=\"Hide details\" ref=\"linksrc=toggle_article_details\" aria-controls=\"full-article-details\" aria-expanded=\"false\" data-fetch-url=\"\/42538621\/long-authors\/\" data-id-prefix=\"\"><br \/>\n            <span class=\"title\">Show details<\/span><br \/>\n          <\/button><\/p>\n<div class=\"display-options\" data-format-key=\"format\" data-default-format-value=\"abstract\" data-current-format-value=\"abstract\" role=\"region\">\n  <button class=\"trigger usa-button\" title=\"Change format\" data-ga-category=\"display_options\" data-ga-action=\"display_options_dialog\"><br \/>\n    <span class=\"button-label\">Display options<\/span><br \/>\n  <\/button><\/p>\n<div class=\"dropdown\" hidden=\"\" wp_automatic_readability=\"6\">\n<p>\n      Display options\n    <\/p>\n<div class=\"content\" wp_automatic_readability=\"32\">\n<p>\n          <span class=\"option-label\"><br \/>\n            Format<br \/>\n          <\/span><br \/>\n          <select name=\"format\" data-initial-value=\"abstract\" aria-label=\"Display format\" id=\"mobile-display-format\"><option value=\"abstract\">Abstract<\/option><option value=\"pubmed\">PubMed<\/option><option value=\"pmid\">PMID<\/option><\/select>\n        <\/p>\n<\/p><\/div>\n<\/p><\/div>\n<\/div><\/div>\n<div class=\"extended-article-details\" id=\"full-article-details\" aria-hidden=\"true\">\n<div class=\"expanded-authors\" id=\"short-view-expanded-authors\">\n<div class=\"affiliations\">\n<h3 class=\"title\">\n            Affiliations<br \/>\n          <\/h3>\n<ul class=\"item-list\">\n<li data-affiliation-id=\"short-view-affiliation-1\" id=\"short-view-affiliation-1\"><sup class=\"key\">1<\/sup> Department of Pharmacy, School of Applied Sciences, University of Huddersfield, Huddersfield, UK.<\/li>\n<li data-affiliation-id=\"short-view-affiliation-2\" id=\"short-view-affiliation-2\"><sup class=\"key\">2<\/sup> Clinic for Tumors, Clinical Hospital Centre Rijeka, Rijeka, Croatia.<\/li>\n<li data-affiliation-id=\"short-view-affiliation-3\" id=\"short-view-affiliation-3\"><sup class=\"key\">3<\/sup> Department of Basic and Clinical Pharmacology With Toxicology, Faculty of Medicine, University of Rijeka, Rijeka, Croatia.<\/li>\n<\/ul><\/div>\n<\/p><\/div>\n<p>\n  Item in Clipboard\n<\/p>\n<\/p><\/div>\n<\/p><\/div>\n<\/header>\n<div class=\"actions-buttons inline\">\n<div class=\"inner-wrap\"><button class=\"full-text-links-button full-text-links-dialog-trigger\" title=\"Open dialog with full text links\" ref=\"linksrc=full_text_links\"><br \/>\n          Full text links<br \/>\n        <\/button><button class=\"citation-button citation-dialog-trigger\" aria-label=\"Open dialog with citation text in different styles\" data-ga-category=\"save_share\" data-ga-action=\"cite\" data-ga-label=\"open\" data-all-citations-url=\"\/42538621\/citations\/\" data-citation-style=\"nlm\" data-pubmed-format-link=\"\/42538621\/export\/\"><span class=\"button-label\">Cite<\/span><\/button><button class=\"more-actions-button more-actions-dialog-trigger\" title=\"Open dialog with more actions to take\" ref=\"linksrc=more_actions_btn\"\/><\/p>\n<div class=\"display-options\" data-format-key=\"format\" data-default-format-value=\"abstract\" data-current-format-value=\"abstract\" role=\"region\"><button class=\"trigger usa-button\" title=\"Change format\" data-ga-category=\"display_options\" data-ga-action=\"display_options_dialog\"><span class=\"button-label\">Display options<\/span><\/button><\/p>\n<div class=\"dropdown\" hidden=\"\" wp_automatic_readability=\"6\">\n<p>\n      Display options\n    <\/p>\n<div class=\"content\" wp_automatic_readability=\"32\">\n<p><span class=\"option-label\"><br \/>\n            Format<br \/>\n          <\/span><select name=\"format\" data-initial-value=\"abstract\" aria-label=\"Display format\" id=\"inline-actions-display-format\"><option value=\"abstract\">Abstract<\/option><option value=\"pubmed\">PubMed<\/option><option value=\"pmid\">PMID<\/option><\/select><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"abstract\" id=\"abstract\" wp_automatic_readability=\"13\">\n<h2 class=\"title\">\n        Abstract<\/p>\n<\/h2>\n<div class=\"abstract-content selected\" id=\"eng-abstract\" wp_automatic_readability=\"42\">\n<p>      Despite advances in targeted and immunotherapy for melanoma, resistance to treatment and severe adverse effects pose significant challenges. This necessitates the development of new treatment strategies, and cannabinoids, because of the extensive preclinical evidence for their cytotoxic action on carcinoma cells in a variety of cancers, can offer a novel therapeutic option when used appropriately. Indeed, the potential therapeutic benefits of cannabinoids were formally recognized in the world and much more recently in the United Kingdom when cannabis-based medicinal products were moved from Schedule 1 of the Misuse of Drugs Regulations 2001 to Schedule 2 in 2018. This move further encouraged scientists to look at more applications of cannabinoids in different disorders. Although the potential psychoactivity of cannabis as a Schedule 1 drug hinders research, more research could focus on non-psychoactive components such as cannabidiol (CBD) and cannabigerol (CBG). This review summarizes some past and current research on the relationship between the cannabinoid system and the microbiome in patients with metastatic melanoma who undergo immunotherapy. The review also provides a comprehensive background on the function of the cannabinoid system in normal and diseased skin, as well as future directions in using cannabinoids as an adjunct to chemotherapeutics in the treatment of the disease.\n    <\/p>\n<\/p><\/div>\n<p>        <strong class=\"sub-title\"><br \/>\n          Keywords:<br \/>\n        <\/strong><\/p>\n<p>      cannabinoids; gut microbiome; melanoma; skin cancer.\n    <\/p>\n<\/p><\/div>\n<p class=\"copyright\" id=\"copyright\">\n    \u00a9 2026 The Author(s). Pharmacology Research &amp; Perspectives published by British Pharmacological Society and John Wiley &amp; Sons Ltd.\n  <\/p>\n<p class=\"disclaimer\" id=\"disclaimer\">\n  <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/disclaimer\/\" target=\"_blank\" data-ga-category=\"literature_resources\" data-ga-action=\"disclaimer_link\" data-ga-label=\"under_abstract\">PubMed Disclaimer<\/a>\n<\/p>\n<div class=\"conflict-of-interest\" id=\"conflict-of-interest\" wp_automatic_readability=\"6\">\n<h2 class=\"title\">\n      Conflict of interest statement<br \/>\n    <\/h2>\n<div class=\"statement\" wp_automatic_readability=\"7\">\n<p xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xmlns:p1=\"http:\/\/pubmed.gov\/pub-one\">The authors declare no conflicts of interest.<\/p>\n<\/p><\/div>\n<\/p><\/div>\n<div class=\"figures\" id=\"figures\">\n<h2 class=\"title\">\n          Figures<br \/>\n        <\/h2>\n<div class=\"figures-list\" id=\"slides-container\" itemscope=\"\" itemtype=\"http:\/\/schema.org\/ImageGallery\">\n<figure class=\"figure-item \" itemscope=\"\" itemtype=\"http:\/\/schema.org\/ImageObject\" itemprop=\"associatedMedia\" data-slide-index=\"0\" data-label-slug=\"figure-1\" wp_automatic_readability=\"4.5\">\n              <a class=\"figure-link\" href=\"https:\/\/cdn.ncbi.nlm.nih.gov\/pmc\/blobs\/3d83\/13428027\/c8ab7ca9b2f9\/PRP2-14-e70304-g003.jpg\" itemprop=\"contentUrl\" aria-describedby=\"figure-caption-0\" role=\"button\" data-image-width=\"709\" data-image-height=\"351\" data-image-alt=\"FIGURE 1\" data-pmc-id=\"PMC13428027\" data-figure-id=\"prp270304-fig-0001\"><br \/>\n                <img decoding=\"async\" class=\"figure-thumb\" itemprop=\"thumbnail\" id=\"article-image-0\" src=\"https:\/\/cdn.ncbi.nlm.nih.gov\/pmc\/blobs\/3d83\/13428027\/a43f2590a85d\/PRP2-14-e70304-g003.gif\" alt=\"FIGURE 1\"\/><br \/>\n              <\/a><\/p>\n<p>              <meta itemprop=\"width\" itemtype=\"http:\/\/schema.org\/ImageObject\" content=\"709\"\/><br \/>\n              <meta itemprop=\"height\" itemtype=\"http:\/\/schema.org\/ImageObject\" content=\"351\"\/><\/p>\n<div class=\"figure-caption figure-caption-text\" itemtype=\"http:\/\/schema.org\/ImageObject\" itemprop=\"caption\" aria-hidden=\"true\">\n<div class=\"caption-wrap\" wp_automatic_readability=\"6\">\n<p>    <strong class=\"figure-label\"><\/p>\n<p> FIGURE 1 <\/p>\n<p>    <\/strong><\/p>\n<div class=\"figure-caption-contents\" wp_automatic_readability=\"32\">\n<p> Cannabinoid and non\u2010cannabinoid receptors in\u2026 <\/p>\n<\/div><\/div>\n<\/p><\/div>\n<div class=\"figure-caption-medium figure-caption-text\" aria-hidden=\"true\" wp_automatic_readability=\"31.5\">\n<p>    <strong class=\"figure-label\"><\/p>\n<p> FIGURE 1 <\/p>\n<p>    <\/strong><\/p>\n<div class=\"figure-caption-contents\" wp_automatic_readability=\"33\">\n<p> Cannabinoid and non\u2010cannabinoid receptors in human skin. Physiological functions of the endocannabinoid system.\u2026 <\/p>\n<\/div><\/div><figcaption id=\"figure-caption-0\" class=\"figure-caption-full figure-caption-text\" itemtype=\"http:\/\/schema.org\/ImageObject\" itemprop=\"description\" wp_automatic_readability=\"34\">\n<p>    <strong class=\"figure-label\"><br \/>\n      FIGURE 1<br \/>\n    <\/strong><\/p>\n<p>Cannabinoid and non\u2010cannabinoid receptors in human skin. Physiological functions of the endocannabinoid system. This figure illustrates the key components of the endocannabinoid system in human skin, highlighting CB and non\u2010CB receptors in different skin compartments, such as sebocytes derived from keratinocytes, epidermal, and sebaceous glands. Anandamide in human keratinocytes can induce an inhibition of epidermal cell differentiation by inhibiting protein kinase C activation via CB<sub>1<\/sub> receptors.<\/p>\n<\/figcaption><\/figure>\n<figure class=\"figure-item \" itemscope=\"\" itemtype=\"http:\/\/schema.org\/ImageObject\" itemprop=\"associatedMedia\" data-slide-index=\"1\" data-label-slug=\"figure-2\" wp_automatic_readability=\"3\">\n              <a class=\"figure-link\" href=\"https:\/\/cdn.ncbi.nlm.nih.gov\/pmc\/blobs\/3d83\/13428027\/fd5be3705478\/PRP2-14-e70304-g001.jpg\" itemprop=\"contentUrl\" aria-describedby=\"figure-caption-1\" role=\"button\" data-image-width=\"665\" data-image-height=\"454\" data-image-alt=\"FIGURE 2\" data-pmc-id=\"PMC13428027\" data-figure-id=\"prp270304-fig-0002\"><br \/>\n                <img decoding=\"async\" class=\"figure-thumb\" itemprop=\"thumbnail\" id=\"article-image-1\" src=\"https:\/\/cdn.ncbi.nlm.nih.gov\/pmc\/blobs\/3d83\/13428027\/ddcf902979ec\/PRP2-14-e70304-g001.gif\" alt=\"FIGURE 2\"\/><br \/>\n              <\/a><\/p>\n<p>              <meta itemprop=\"width\" itemtype=\"http:\/\/schema.org\/ImageObject\" content=\"665\"\/><br \/>\n              <meta itemprop=\"height\" itemtype=\"http:\/\/schema.org\/ImageObject\" content=\"454\"\/><\/p>\n<div class=\"figure-caption figure-caption-text\" itemtype=\"http:\/\/schema.org\/ImageObject\" itemprop=\"caption\" aria-hidden=\"true\">\n<div class=\"caption-wrap\" wp_automatic_readability=\"6\">\n<p>    <strong class=\"figure-label\"><\/p>\n<p> FIGURE 2 <\/p>\n<p>    <\/strong><\/p>\n<div class=\"figure-caption-contents\" wp_automatic_readability=\"32\">\n<p> Relationship between cannabinoids and gut\u2026 <\/p>\n<\/div><\/div>\n<\/p><\/div>\n<div class=\"figure-caption-medium figure-caption-text\" aria-hidden=\"true\" wp_automatic_readability=\"31.5\">\n<p>    <strong class=\"figure-label\"><\/p>\n<p> FIGURE 2 <\/p>\n<p>    <\/strong><\/p>\n<div class=\"figure-caption-contents\" wp_automatic_readability=\"33\">\n<p> Relationship between cannabinoids and gut microbiome. This figure illustrates how cannabinoids influence the\u2026 <\/p>\n<\/div><\/div><figcaption id=\"figure-caption-1\" class=\"figure-caption-full figure-caption-text\" itemtype=\"http:\/\/schema.org\/ImageObject\" itemprop=\"description\" wp_automatic_readability=\"31\">\n<p>    <strong class=\"figure-label\"><br \/>\n      FIGURE 2<br \/>\n    <\/strong><\/p>\n<p>Relationship between cannabinoids and gut microbiome. This figure illustrates how cannabinoids influence the composition of the intestinal microbiota, promoting beneficial bacterial strains such as <i>Akkermansia muciniphila<\/i>. Changes in the intestinal microbiota can regulate the activity of the endocannabinoid system by modulating CB<sub>1<\/sub> and CB<sub>2<\/sub> receptors in the gastrointestinal tract. A higher number of <i>Bacteroides<\/i> species is related to metabolic problems and intestinal inflammation.<\/p>\n<\/figcaption><\/figure>\n<\/p><\/div>\n<p>        <!-- Root element of PhotoSwipe. Must have class pswp. --><\/p><\/div>\n<div class=\"references\" id=\"references\">\n<h2 class=\"title\">\n      References<br \/>\n    <\/h2>\n<div id=\"top-references-list\" class=\"references-lists-container\">\n<div class=\"refs-list\">\n<ol id=\"top-references-list-1\" class=\"references-list\">\n<li>\n<ol class=\"references-and-notes-list\">\n<li class=\"skip-numbering\" value=\"1\">\n<p>            Elder D. E., Bastian B. C., Cree I. A., Massi D., and Scolyer R. A., \u201cThe 2018 World Health Organization Classification of Cutaneous, Mucosal, and Uveal Melanoma: Detailed Analysis of 9 Distinct Subtypes Defined by Their Evolutionary Pathway,\u201d Archives of Pathology &amp; Laboratory Medicine 144, no. 4 (2020): 500\u2013522.<\/p>\n<p>                  &#8211;<br \/>\n                  <a class=\"reference-link\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32057276\/\" ref=\"linksrc=references_link&amp;ordinalpos=1\" data-ga-category=\"reference\" data-ga-action=\"32057276\">PubMed<\/a><\/p>\n<\/li>\n<\/ol>\n<\/li>\n<li>\n<ol class=\"references-and-notes-list\">\n<li class=\"skip-numbering\" value=\"1\">\n<p>            Tas F., \u201cMetastatic Behaviour in Melanoma: Timing, Pattern, Survival, and Influencing Factors,\u201d Journal of Oncology 2012 (2012): 647684, 10.1155\/2012\/647684.<\/p>\n<p>                  &#8211;<br \/>\n                  <a class=\"reference-link usa-link--external\" href=\"https:\/\/doi.org\/10.1155\/2012\/647684\" ref=\"linksrc=references_link&amp;ordinalpos=1\" data-ga-category=\"reference\" data-ga-action=\"10.1155\/2012\/647684\" target=\"_blank rel=\" noreferrer=\"\" aria-label=\"external, opens in new tab. DOI\">DOI<\/a><\/p>\n<p>                  &#8211;<br \/>\n                  <a class=\"reference-link\" href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC3391929\/\" ref=\"linksrc=references_link&amp;ordinalpos=2\" data-ga-category=\"reference\" data-ga-action=\"PMC3391929\">PMC<\/a><\/p>\n<p>                  &#8211;<br \/>\n                  <a class=\"reference-link\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22792102\/\" ref=\"linksrc=references_link&amp;ordinalpos=3\" data-ga-category=\"reference\" data-ga-action=\"22792102\">PubMed<\/a><\/p>\n<\/li>\n<\/ol>\n<\/li>\n<li>\n<ol class=\"references-and-notes-list\">\n<li class=\"skip-numbering\" value=\"1\">\n<p>            Arnold M., Singh D., Laversanne M., et al., \u201cGlobal Burden of Cutaneous Melanoma in 2020 and Projections to 2040,\u201d JAMA Dermatology 158, no. 5 (2022): 495\u2013503.<\/p>\n<p>                  &#8211;<br \/>\n                  <a class=\"reference-link\" href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC8968696\/\" ref=\"linksrc=references_link&amp;ordinalpos=1\" data-ga-category=\"reference\" data-ga-action=\"PMC8968696\">PMC<\/a><\/p>\n<p>                  &#8211;<br \/>\n                  <a class=\"reference-link\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35353115\/\" ref=\"linksrc=references_link&amp;ordinalpos=2\" data-ga-category=\"reference\" data-ga-action=\"35353115\">PubMed<\/a><\/p>\n<\/li>\n<\/ol>\n<\/li>\n<li>\n<ol class=\"references-and-notes-list\">\n<li class=\"skip-numbering\" value=\"1\">\n<p>            Schadendorf D., Van Akkooi A. C. J., Berking C., et al., \u201cMelanoma,\u201d Lancet 392, no. 10151 (2018): 971\u2013984.<\/p>\n<p>                  &#8211;<br \/>\n                  <a class=\"reference-link\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30238891\/\" ref=\"linksrc=references_link&amp;ordinalpos=1\" data-ga-category=\"reference\" data-ga-action=\"30238891\">PubMed<\/a><\/p>\n<\/li>\n<\/ol>\n<\/li>\n<li>\n<ol class=\"references-and-notes-list\">\n<li class=\"skip-numbering\" value=\"1\">\n<p>            Bajetta E., Del Vecchio M., Bernard\u2010Marty C., et al., \u201cMetastatic Melanoma: Chemotherapy,\u201d Seminars in Oncology 29, no. 5 (2002): 427\u2013445.<\/p>\n<p>                  &#8211;<br \/>\n                  <a class=\"reference-link\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/12407508\/\" ref=\"linksrc=references_link&amp;ordinalpos=1\" data-ga-category=\"reference\" data-ga-action=\"12407508\">PubMed<\/a><\/p>\n<\/li>\n<\/ol>\n<\/li>\n<\/ol>\n<p>    <button class=\"show-all\" ref=\"linksrc=show_all_references_link\" aria-controls=\"top-references-list-1\" data-next-page-url=\"\/42538621\/references\/\" data-ga-category=\"reference\" data-ga-action=\"show_more\"><br \/>\n      Show all 119 references<br \/>\n    <\/button><\/p>\n<\/div>\n<\/div><\/div>\n<div id=\"mesh-terms\" class=\"mesh-terms keywords-section\">\n<h2 class=\"title\">\n        MeSH terms<br \/>\n      <\/h2>\n<ul class=\"keywords-list\">\n<li\/>\n<li>\n<div class=\"keyword-actions dropdown-block\"><button class=\"keyword-actions-trigger trigger keyword-link\" aria-label=\"Toggle dropdown menu for keyword Cannabidiol \/ pharmacology\" tabindex=\"0\" aria-controls=\"keyword-actions-mesh-terms-1\" aria-expanded=\"false\" data-pinger-ignore=\"\"><br \/>\n      Cannabidiol \/ pharmacology<br \/>\n    <\/button><\/div>\n<\/li>\n<li>\n<div class=\"keyword-actions dropdown-block\"><button class=\"keyword-actions-trigger trigger keyword-link\" aria-label=\"Toggle dropdown menu for keyword Cannabidiol \/ therapeutic use\" tabindex=\"0\" aria-controls=\"keyword-actions-mesh-terms-2\" aria-expanded=\"false\" data-pinger-ignore=\"\"><br \/>\n      Cannabidiol \/ therapeutic use<br \/>\n    <\/button><\/div>\n<\/li>\n<li>\n<div class=\"keyword-actions dropdown-block\"><button class=\"keyword-actions-trigger trigger keyword-link major\" aria-label=\"Toggle dropdown menu for keyword Cannabinoids* \/ pharmacology\" tabindex=\"0\" aria-controls=\"keyword-actions-mesh-terms-major-3\" aria-expanded=\"false\" data-pinger-ignore=\"\"><br \/>\n      Cannabinoids* \/ pharmacology<br \/>\n    <\/button><\/div>\n<\/li>\n<li>\n<div class=\"keyword-actions dropdown-block\"><button class=\"keyword-actions-trigger trigger keyword-link major\" aria-label=\"Toggle dropdown menu for keyword Cannabinoids* \/ therapeutic use\" tabindex=\"0\" aria-controls=\"keyword-actions-mesh-terms-major-4\" aria-expanded=\"false\" data-pinger-ignore=\"\"><br \/>\n      Cannabinoids* \/ therapeutic use<br \/>\n    <\/button><\/div>\n<\/li>\n<li\/>\n<li\/>\n<li\/>\n<li\/>\n<li\/>\n<li>\n<div class=\"keyword-actions dropdown-block\"><button class=\"keyword-actions-trigger trigger keyword-link major\" aria-label=\"Toggle dropdown menu for keyword Microbiota* \/ drug effects\" tabindex=\"0\" aria-controls=\"keyword-actions-mesh-terms-major-10\" aria-expanded=\"false\" data-pinger-ignore=\"\"><br \/>\n      Microbiota* \/ drug effects<br \/>\n    <\/button><\/div>\n<\/li>\n<li\/>\n<li>\n<div class=\"keyword-actions dropdown-block\"><button class=\"keyword-actions-trigger trigger keyword-link major\" aria-label=\"Toggle dropdown menu for keyword Skin Neoplasms* \/ drug therapy\" tabindex=\"0\" aria-controls=\"keyword-actions-mesh-terms-major-12\" aria-expanded=\"false\" data-pinger-ignore=\"\"><br \/>\n      Skin Neoplasms* \/ drug therapy<br \/>\n    <\/button><\/div>\n<\/li>\n<li>\n<div class=\"keyword-actions dropdown-block\"><button class=\"keyword-actions-trigger trigger keyword-link major\" aria-label=\"Toggle dropdown menu for keyword Skin Neoplasms* \/ immunology\" tabindex=\"0\" aria-controls=\"keyword-actions-mesh-terms-major-13\" aria-expanded=\"false\" data-pinger-ignore=\"\"><br \/>\n      Skin Neoplasms* \/ immunology<br \/>\n    <\/button><\/div>\n<\/li>\n<li>\n<div class=\"keyword-actions dropdown-block\"><button class=\"keyword-actions-trigger trigger keyword-link major\" aria-label=\"Toggle dropdown menu for keyword Skin Neoplasms* \/ microbiology\" tabindex=\"0\" aria-controls=\"keyword-actions-mesh-terms-major-14\" aria-expanded=\"false\" data-pinger-ignore=\"\"><br \/>\n      Skin Neoplasms* \/ microbiology<br \/>\n    <\/button><\/div>\n<\/li>\n<\/ul><\/div>\n<div id=\"linkout\" class=\"linkout\">\n<h2 class=\"title\">\n      LinkOut &#8211; 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Affiliations Expand Affiliations 1 Department of Pharmacy, School of Applied Sciences, University of Huddersfield, Huddersfield, UK. 2 Clinic for Tumors, Clinical Hospital Centre Rijeka, Rijeka, Croatia. 3 Department of Basic and Clinical Pharmacology With Toxicology, Faculty of Medicine, University of Rijeka, Rijeka, Croatia. Item in Clipboard Review Farideh A Javid\u00a0et al. Pharmacol [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":353883,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[135601],"tags":[185895,1683,185896,185897,185898,185899,185892,174581,185893,18867,185900,185894,175060,75411,185901,185902,185903,26739,185904,175058,56813,175059,175057,41397,175056,185891,185890,175055,17663,3749,185905,185906,185907,185908],"dealstore":[],"offerexpiration":[],"class_list":["post-364444","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-hemp","tag-andrej-belancic","tag-animals","tag-cannabidiol-pharmacology","tag-cannabidiol-therapeutic-use","tag-cannabinoids-pharmacology","tag-cannabinoids-therapeutic-use","tag-doi10-1002-prp2-70304","tag-endocannabinoids","tag-farideh-a-javid","tag-humans","tag-immunotherapy-methods","tag-marin-golcic","tag-medline","tag-melanoma","tag-melanoma-drug-therapy","tag-melanoma-immunology","tag-melanoma-microbiology","tag-microbiome","tag-microbiota-drug-effects","tag-national-center-for-biotechnology-information","tag-national-institutes-of-health","tag-national-library-of-medicine","tag-ncbi","tag-nih","tag-nlm","tag-pmc13428027","tag-pmid42538621","tag-pubmed-abstract","tag-relationship","tag-review","tag-skin-microbiome","tag-skin-neoplasms-drug-therapy","tag-skin-neoplasms-immunology","tag-skin-neoplasms-microbiology"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.4 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>The Relationship Between (Endo)cannabinoids, the Microbiome and Melanoma - Som2ny Network<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/fivemor.com\/?p=364444\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"The Relationship Between (Endo)cannabinoids, the Microbiome and Melanoma - Som2ny Network\" \/>\n<meta property=\"og:description\" content=\"Review doi: 10.1002\/prp2.70304. Affiliations Expand Affiliations 1 Department of Pharmacy, School of Applied Sciences, University of Huddersfield, Huddersfield, UK. 2 Clinic for Tumors, Clinical Hospital Centre Rijeka, Rijeka, Croatia. 3 Department of Basic and Clinical Pharmacology With Toxicology, Faculty of Medicine, University of Rijeka, Rijeka, Croatia. Item in Clipboard Review Farideh A Javid\u00a0et al. 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Affiliations Expand Affiliations 1 Department of Pharmacy, School of Applied Sciences, University of Huddersfield, Huddersfield, UK. 2 Clinic for Tumors, Clinical Hospital Centre Rijeka, Rijeka, Croatia. 3 Department of Basic and Clinical Pharmacology With Toxicology, Faculty of Medicine, University of Rijeka, Rijeka, Croatia. Item in Clipboard Review Farideh A Javid\u00a0et al. 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