{"id":321869,"date":"2025-11-27T17:17:31","date_gmt":"2025-11-27T17:17:31","guid":{"rendered":"https:\/\/peraltafinancing.com\/uncategorized\/rhr-the-science-behind-oral-inflammation-with-dr-william-levine\/"},"modified":"2025-11-27T17:17:31","modified_gmt":"2025-11-27T17:17:31","slug":"rhr-the-science-behind-oral-inflammation-with-dr-william-levine","status":"publish","type":"post","link":"https:\/\/fivemor.com\/?p=321869","title":{"rendered":"RHR: The Science Behind Oral Inflammation, with Dr. William Levine"},"content":{"rendered":"<p> <br \/>\n<\/p>\n<div wp_automatic_readability=\"747.22436699593\">\n<p><b>In this episode, we discuss:<\/b><\/p>\n<ul>\n<li aria-level=\"1\">How periodontal disease develops and impacts the body<\/li>\n<li aria-level=\"1\">Recognizing symptoms of periodontal disease<\/li>\n<li aria-level=\"1\">Conventional and modern treatments for standard chronic periodontal disease<\/li>\n<li aria-level=\"1\">How to prevent gum disease<\/li>\n<li aria-level=\"1\">Emerging technologies in periodontal care<\/li>\n<li aria-level=\"1\">The future of frequency medicine and personalized care<\/li>\n<\/ul>\n<p><b>Show notes:<\/b><\/p>\n<p><noscript><iframe loading=\"lazy\" title=\"RHR: The Science Behind Oral Inflammation, with Dr. William Levine\" width=\"840\" height=\"473\" src=\"https:\/\/www.youtube.com\/embed\/o3BJ3GrXNrs?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe><\/noscript><\/p>\n<p><iframe loading=\"lazy\" style=\"border: none;\" title=\"Libsyn Player\" src=\"https:\/\/chriskresser.com\/the-science-behind-oral-inflammation-with-dr-william-levine\/about:blank\" width=\"100%\" height=\"90\" scrolling=\"no\" allowfullscreen=\"allowfullscreen\" data-rocket-lazyload=\"fitvidscompatible\" data-lazy-src=\"https:\/\/html5-player.libsyn.com\/embed\/episode\/id\/38373740\/height\/90\/theme\/custom\/thumbnail\/yes\/direction\/backward\/render-playlist\/no\/custom-color\/87A93A\/\"><\/iframe><noscript><iframe loading=\"lazy\" style=\"border: none;\" title=\"Libsyn Player\" src=\"https:\/\/html5-player.libsyn.com\/embed\/episode\/id\/38373740\/height\/90\/theme\/custom\/thumbnail\/yes\/direction\/backward\/render-playlist\/no\/custom-color\/87A93A\/\" width=\"100%\" height=\"90\" scrolling=\"no\" allowfullscreen=\"allowfullscreen\"><\/iframe><\/noscript><\/p>\n<p style=\"font-weight: 400;\">Hey everyone, Chris Kresser here. Welcome to another episode of <em>Revolution Health Radio<\/em>. Over the years, I\u2019ve talked about the importance of oral and periodontal health, not just for the health of our teeth and our mouth, but for our overall health. We now know that there\u2019s a strong connection between periodontal disease and everything from heart disease to autoimmune conditions, because the bacteria in the mouth can get into the bloodstream and then provoke a systemic inflammatory autoimmune reaction.<\/p>\n<p style=\"font-weight: 400;\">Today I\u2019m really excited to welcome Dr. William Levine, or Bill Levine. He\u2019s a board certified periodontist with 35 years of experience in treating oral inflammation. He is also on the cutting edge of treatments like PRP, infrared light, laser photobiomodulation, and even PEMF, as we discuss towards the end of the show, as a way of safely but effectively treating oral and gum problems. It was a fascinating conversation. We talk about the overlooked role of gums in health, why it\u2019s so important, how to know if you might be suffering from gum disease that could be affecting your systemic health, the best ways to prevent gum disease from happening, the most effective treatments, and then, as I just mentioned, some of the newer treatments that we can look forward to in the coming years. I really learned a lot, and I hope you do too. Let\u2019s dive in. ^p^p<\/p>\n<p style=\"font-weight: 400;\"><strong>Chris Kresser:<\/strong>\u00a0 Dr. Bill Levine, welcome to the show. Pleasure to have you.<\/p>\n<p style=\"font-weight: 400;\"><strong>Bill Levine:\u00a0 <\/strong>Thank you very much, Chris. It\u2019s a pleasure to be here. Thank you for inviting me.<\/p>\n<h2>How Periodontal Disease Develops and Impacts the Body<\/h2>\n<p style=\"font-weight: 400;\"><strong>Chris Kresser:\u00a0 <\/strong>I\u2019m excited about this topic. I\u2019ve spoken with a couple of other physicians in the past about the important role of periodontal health in overall health. And I actually just saw a study a few days ago come out. I\u2019m not sure if you saw it. It was, I think the title was something like, is heart disease infectious? And the premise was that bacteria in the mouth due to periodontal disease then travels into the bloodstream and can eventually cause heart attacks and other heart problems. This isn\u2019t a new finding, of course, but it was timely, because I was thinking about our podcast coming up in a couple of days. So maybe let\u2019s start there, not necessarily with that specific study, especially if you haven\u2019t seen it, but just a broader overview of what is so important about periodontal health above and beyond just the health of our mouth.<\/p>\n<p style=\"font-weight: 400;\"><strong>Bill Levine:\u00a0 <\/strong>So first of all, I actually had seen that article because it was of interest, and it\u2019s an interesting finding that actually surprised the world. It\u2019s not new, this information. It keeps pouring into us over the last 20, 25, years, which is quite a long time in the healthcare area. But even as dentists, we didn\u2019t quite realize the impact that dentistry, or let\u2019s say oral health has on our systemic health. Well, let me sort of start the story by describing what\u2019s going on in periodontal disease, and then we could sort of, it will shed light, really, on the impact it has on systemic health.<\/p>\n<p style=\"font-weight: 400;\">Periodontal disease basically comes from the fact that our teeth are anchored into our bone and yet that has to be a sterile environment. Yet they function in the oral cavity, the mouth, which is a completely unsterile environment. So the way it manages it is, there are a special group of cells that surround the neck of the tooth, glue on an adhesion, it\u2019s a biological glue and a cellular glue that seal off the internal sterile area from the mouth. But in order to maintain that sterility, they often get subject to different attacks, of infections, trauma and various other potential insults, which can damage the seal and therefore penetrate within. So they have an array of very potent localized means, cellular and vascular and chemical in a sense, but biologic chemicals, to fight off these damaging insults, and at the same time, help quickly repair the seal and reset it. But sometimes what happens is the area is under such continuous insult that it\u2019s sort of like a computer in overload, and it goes into overdrive. And that immune function which is designed to protect you actually starts to cause damage. And the damage that it causes results in a loss of bone and the loss of the seal, and then they develop spaces between the gum and the tooth. The gum may stay where it is, but the seal is still there.<\/p>\n<p style=\"font-weight: 400;\">Anyway, what we\u2019re left with, I was describing, is the environment in the destroyed bone from the chronic activation of the inflammatory system. So now let\u2019s sort of drill down for a brief second as to what that looks like. It\u2019s a space between the gum and the tooth that has an environment that\u2019s great for growing pathologic bacteria. It\u2019s warm, it\u2019s got plenty of nutrients. It\u2019s protected from your brushing, and it\u2019s protected from the immune effect because [there\u2019s] less vascularity there. And at the same time, the tissue that\u2019s adjacent to it is inflamed, permeable and ulcerated. So those bacteria then are spewing bacteria into your bloodstream at the capillary level in your gums, and they\u2019re traveling throughout the body in a reasonably significant amount, on a constant basis. So what happens is these pathologic bacteria can both have an impact in different areas in the heart, let\u2019s say, by lodging the bacteria in cardiac plaques and activating them by enlarging in certain irregularities, like different valves that are not functioning perfectly, and they could actually cause a significant amount of problems.<\/p>\n<p style=\"font-weight: 400;\">But there\u2019s another aspect of the problem. Remember what we said earlier, the inflammatory response of the body, which, in a sense, is supposed to protect you, is activated. So you have all these inflammatory mediators which are driving the inflammatory process locally, but they\u2019re also leaking into the bloodstream. So you\u2019ve got a big rise in what we would call your inflammatory profile in a negative way. So the body is constantly stressed now because it\u2019s reacting to both chronic infection and a constant pro-inflammatory, or inflammatory driver that\u2019s stimulating the system. So in general, it affects your health overall. So yes, it affects cardiac effects, and we\u2019ve actually found oral bacteria lodged in blockages in the heart as part of the problem. And they\u2019re, by the way, activating an inflammatory response in the cardiac tissue that\u2019s next to that. So it\u2019s a complex of arrays, but both infectious and inflammatory, which causes so many different diseases, not just cardiac. Also, it impacts on fetal health in pregnant women. This is highly significant. It impacts on an increase in dementia. It increases an impact of cancer susceptibility, rheumatoid arthritis and regular arthritis. I can go on and on and on, but basically, you have a large area of sepsis and pro-inflammatory mediators affecting your system, which will have a big effect in this.<\/p>\n<p style=\"font-weight: 400;\">And so that\u2019s why oral care and prevention and periodontal treatment specifically is so critical to maintaining your overall health. And people often don\u2019t pay attention to it, frankly, because it\u2019s really hard to imagine that it\u2019s so significant. But the level of significance is right up there with obesity and smoking.<\/p>\n<p style=\"font-weight: 400;\"><strong>Chris Kresser:\u00a0 <\/strong>Yeah, I think that\u2019s such an important point. I just want to linger on that for a minute, because many people now have heard and understand that inflammation is at the root of almost all modern chronic disease, and I think they understand that on some level, but then they may not be aware that gum disease is one of the primary sources of inflammation, and it\u2019s often hidden. You mentioned the association with gum disease and rheumatoid arthritis, which, of course, is an autoimmune disease, and you mentioned the immune inflammatory effects that gum disease can have. We\u2019re really suffering from an epidemic of autoimmune disease now. Some estimates suggest that between one and four and one in six women have some kind of autoimmune disease, and it just continues to increase every year. And when I, in the clinic, if I saw a patient with autoimmune disease from a functional medicine perspective, we were always trying to uncover the root cause of that overly aggressive immune response. And the gut was, of course, often one of the main places to look, but the other end of the digestive tract, in the mouth, was another primary place to look. That was not work that I did myself because I\u2019m not a dentist, but I would often refer people to dentists and periodontists to get a workup if they were suffering from any kind of autoimmune condition. Because if they have that as a trigger, it can be very difficult to recover or reach any kind of remission in autoimmunity, because you have that trigger that\u2019s constantly firing and dysregulating the immune system.<\/p>\n<p style=\"font-weight: 400;\">So we can move on from here. This is a good segue to how people can figure out if this is affecting them? First question is, will there always be obvious symptoms in the mouth that would alert them? Or is it possible that this is going on and they may not be aware of it?<\/p>\n<h2>Recognizing Symptoms and Diagnosis<\/h2>\n<p style=\"font-weight: 400;\"><strong>Bill Levine:\u00a0 <\/strong>Great question. And so I think 90 percent of the people will notice if they have gum disease, because the gums will be swollen to different degrees, obviously, depending on the severity of the disease. Generally, the swollen tissue will be inflamed and bleeding. So the classic, easy to diagnose symptoms would be sensitivity to the gums, a little bit swollen gums, bleeding when either you brush, eat, or just spontaneously. Those are really easy to notice and really easy not to pay attention to. Because you rinse your mouth out, you\u2019ve stopped bleeding. So we move on, and everybody\u2019s busy. But you should have that as a yellow light that you need to schedule a visit with a health professional, in this case, a dentist.<\/p>\n<p style=\"font-weight: 400;\"><strong>Chris Kresser:\u00a0 <\/strong>And will a dentist be able to pick up on this typically? Or does someone need to see a periodontist? Does a referral happen to the periodontist only if the gum disease is advanced, or if there is gum disease? How does the process typically work? Is this something that would be picked up during a typical dental exam, I would assume?<\/p>\n<p style=\"font-weight: 400;\"><strong>Bill Levine:\u00a0 <\/strong>In theory, yes, it should be. Not every dentist pays attention to those signs and symptoms as much as they should. But so yes, your periodontist will always pick it up. A good hygienist will almost always pick it up. The dentist will generally pick it up. And if you have a good dentist, someone you trust, and you ask him, specifically, do I have gum disease, the least he\u2019ll do is send you to the hygienist in his office to help, and she can pursue it from there. I don\u2019t think every case needs to go to a periodontist, but I think that you will always get care from the periodontist if you need it. So, but advanced cases and moderate and advanced cases should certainly go there. That\u2019s already a sign you have some bone loss, and you don\u2019t want to ignore it, because it\u2019s going to progress. And it\u2019s actually, [with] today\u2019s technologies that are available, we can reverse a lot of this. So the more we have to work with and the earlier we pick it up, the more likely it is that we\u2019ll be able to help you keep your teeth for the rest of your life.<\/p>\n<p style=\"font-weight: 400;\"><strong>Chris Kresser:\u00a0 <\/strong>Yeah. Ben Franklin had it right. An ounce of prevention is worth a pound of cure.<\/p>\n<p style=\"font-weight: 400;\"><strong>Bill Levine:\u00a0 <\/strong>Absolutely.<\/p>\n<p style=\"font-weight: 400;\"><strong>Chris Kresser:\u00a0 <\/strong>If it\u2019s too late for prevention, meaning you already have some signs, certainly earlier is better than later in almost all cases with any kind of progressive chronic disease.<\/p>\n<p style=\"font-weight: 400;\"><strong>Bill Levine:\u00a0 <\/strong>Completely agree.<\/p>\n<h2>Conventional and Modern Treatments<\/h2>\n<p style=\"font-weight: 400;\"><strong>Chris Kresser:\u00a0 <\/strong>Let\u2019s move on to that next step. So let\u2019s, if we\u2019re going along the timeline here, someone\u2019s gone to the dentist. They\u2019ve discovered that they have some form of gum disease. What are the treatments that can be applied here and how effective are they?<\/p>\n<p style=\"font-weight: 400;\"><strong>Bill Levine:\u00a0 <\/strong>So let\u2019s talk about standard chronic periodontal disease, the way we described it earlier. Because there are other forms of periodontal disease that I\u2019m going to leave out of this matrix, because they\u2019re treated quite differently. There\u2019s gum recession, which can be sometimes very severe, and potentially put the tooth at risk for survival and esthetically compromising. But if we go back to the story that we spoke about earlier, where they have breakdown in the bone, a space which we actually call a pocket, because if you think about it, it\u2019s like a pocket where it looks like the gum is covering it on the outside. But actually there\u2019s a space between the outside and the shirt, in this case, the outside of the gum and the bone. And so what we need first, is to help to reset the system. We need to reduce the bacterial population and switch that bacterial population over from being a pathologic bacteria to being a healthy bacteria. Those two factors are the basis to start the process. And then you hope that the immune system will also reset itself, which 85 to 90 percent of the time it will do. If your cleaning is thorough, and you deactivate the insult to the system which is activating it, then it will reset itself, naturally.<\/p>\n<p style=\"font-weight: 400;\">It will take time, though and it\u2019s not a simple one session cleaning, because there\u2019s damage here. So the first thing you need to do is go through a thorough schedule of whatever your dentist determines will be necessary. Once that\u2019s the case, you need to remain on a maintenance program with the periodicities [that have] to be set up based on the severity of the disease and the compliance of the patient. That\u2019s really the concept behind it. Now, let\u2019s say, for example, we do that and we\u2019re not able to reset the system, or not able to clean out all the insults. Well there\u2019s, thank goodness, a lot of treatments that are available. In the old days the treatment was, if the deeper cleaning doesn\u2019t work, then let\u2019s do surgery. Which wasn\u2019t illogical, but it\u2019s hard for the patient. It\u2019s an invasive procedure, which not everybody wants to undergo. But nowadays we have and are doing a lot of much more conservative work with laser therapy and different kinds of therapies to switch over the bacterial population, sometimes probiotics to shift the microbiome back into a healthy one. So there\u2019s a lot of different opportunities, and thank goodness the field has progressed, and patients should really just be aware of what options are available to them before they commit to surgery.<\/p>\n<p style=\"font-weight: 400;\"><strong>Chris Kresser:\u00a0 <\/strong>Yeah, it makes sense. Surgery is sometimes necessary, but perhaps a last resort, before other things are considered. Let\u2019s kind of go backwards now and talk about prevention. Because, as we both agree, it\u2019s better to prevent it if you possibly can. So what are some of the steps that people can take on a day to day basis, from oral hygiene and basic habits to prevent gum disease from happening in the first place?<\/p>\n<h2>How To Prevent Gum Disease<\/h2>\n<p style=\"font-weight: 400;\"><strong>Bill Levine:\u00a0 <\/strong>So the first thing is, we want to stay consistent with our story, which is important to remember what the etiology or the cause of periodontal disease is. And you said it a bunch of times yourself. It\u2019s not an autoimmune disease, but it is an inflammatory disease. And so basically, what you want to do is prevent the insults to the tissue. That\u2019s the first thing. So assuming you have no disease at this stage, you need to brush effectively, and then you also need to remember that your teeth have four sides, not including the side that you\u2019re chewing on. So that means when you\u2019re brushing, you\u2019re only cleaning the tongue side or the cheek side or the lip side, but you\u2019re not cleaning between the teeth. So you need to either choose your weapon in a sense that you\u2019re going to use. Some people use floss very effectively, but some people find it very difficult. Some people use what\u2019s called interdental cleaners, which are little devices which can go in between your teeth. And if you use them gently, they certainly don\u2019t cause damage, and they cause a tremendous amount of benefit. So again, you need to figure out what works for you, but make sure that it works for you and that you\u2019re doing it on a consistent basis. Because remember, the mouth is naturally a habitat that is filled with bacteria. Bacteria like to lodge in places, that\u2019s what they do. Hours after you\u2019ve cleaned the surface off, they\u2019re beginning to reform, so you need to really remove them a minimum of twice a day. And I think that should be enough, certainly if you\u2019re doing it in an efficient way.<\/p>\n<p style=\"font-weight: 400;\"><strong>Chris Kresser:\u00a0 <\/strong>How about diet? Other factors, exercise. Just curious what research suggests in terms of lifestyle.<\/p>\n<p style=\"font-weight: 400;\"><strong>Bill Levine:\u00a0 <\/strong>It\u2019s a good question. There\u2019s very little data supporting exercise and overall well being, for a very simple reason. Nobody\u2019s really doing that research, because it\u2019s really hard research to do. Because it\u2019s such a hard thing to measure, and the switch will be small. But I completely agree with you, I believe, even though you didn\u2019t express your opinion here. But you have, the healthier you are, and the healthier your immune system knows how to react, then the healthier the response will be. Because, I want to make an important point here, inflammation is not all bad. Inflammation is also good. Let\u2019s say, for example, you have trauma to your body, you actually need an inflammatory response to take care of it. So what we do is we divide inflammation into two constructs. One is reactive inflammation, which is a response to a trauma, resolves and it\u2019s helpful in resolving the trauma. The other one is chronic inflammation, or dysregulated inflammation, as you used the term before, where the inflammation actually becomes part of the problem. So if you get a blow to your shoulder and it swells up and it hurts for a little while, that\u2019s fine, as long as it keeps getting better. But when that shoulder, after a month, is still swollen and inflamed, your inflammatory process is not working, and you now need to figure out how you\u2019re going to get that under control.<\/p>\n<p style=\"font-weight: 400;\"><strong>Chris Kresser:\u00a0 <\/strong>Yeah, I mean, I think that makes perfect sense, in that the body is an integrated whole. It\u2019s not just a collection of parts that are mashed together, and the immune system is what governs inflammation, right? As you pointed out, both healthy inflammation that we need to heal from wounds and other insults, and then chronic inflammation that can cause disease. And the immune system requires a lot of different nutrients to function properly. And many of us have heard of these. Vitamin C is an example, but there are many others, and if we\u2019re deficient in those nutrients, our immune system isn\u2019t going to function well. Another connection would be the gut immune response. We know 70 percent of the immune system is in the gut, so having a healthy gut microbiome will help your immune system to function better.<\/p>\n<p style=\"font-weight: 400;\">So that\u2019s definitely something that I would focus on with my patients in the clinic, and would see a bi-directional relationship between gut health and oral health where poor oral health can actually lead to poor gut health, and poor gut health can lead to poor oral health. So it makes sense to me that those things would be connected.<\/p>\n<p style=\"font-weight: 400;\">Let\u2019s talk about some other ways to maybe boost prevention. Perhaps we haven\u2019t talked about this yet, actually. What are the risk factors for gum disease? Is there a genetic predisposition? Like, if somebody has identified themselves as potentially at higher risk for any reason, maybe they had gum disease before that has now improved, but they want to take more active steps, whether they\u2019re healthy or whether they\u2019re, they have some history of gum disease. What are those additional steps that could give them more protection?<\/p>\n<p style=\"font-weight: 400;\"><strong>Bill Levine:\u00a0 <\/strong>So there\u2019s definitely a genetic predilection for gum disease. But having a genetic predilection does not mean you\u2019re going to have gum disease. So if your parents have gum disease, there\u2019s a likelihood that you are now at risk, and just like if your parents both had heart attacks when they\u2019re a young age, you should be more aware of what\u2019s going on with your cardiac system. So that being the case, if you know you\u2019re at risk, then you should take greater care. Make sure you\u2019re seeing a periodontist or a dentist. In this case, if you feel like the risk is high, make it a periodontist, and then you should try to manage that. But remember, it\u2019s not a death sentence. It doesn\u2019t mean that, because your parents had periodontal disease, you will suffer. You can prevent this. Yes, you\u2019re at a higher risk. Yes, you may need more intervention. Yes, you maybe need a little bit more prevention. We have a lot of cases in our office where that\u2019s exactly what we\u2019re doing. And care in everything, whether it\u2019s functional medicine, whether it\u2019s diet, whether it\u2019s periodontal care, needs to be customized and personalized to the person that you\u2019re treating. Because it\u2019s not simply one size fits all.<\/p>\n<p style=\"font-weight: 400;\"><strong>Chris Kresser:<\/strong>\u00a0 Absolutely.<\/p>\n<p style=\"font-weight: 400;\"><strong>Bill Levine:\u00a0 <\/strong>So, and that\u2019s that was part of what you\u2019re saying here, in terms of the genetic predisposition. Those patients can be managed and protected as well. I want to dial back to an earlier conversation, because one of the pieces that we use in prevention in our office is a special mouthwash called <a href=\"https:\/\/www.getperiactive.com\/\" target=\"_blank\" rel=\"noopener\">PeriActive<\/a>. And the reason I\u2019m suggesting that, and the reason it was developed, and I was part of the development team, is that, if we remember what was the cause, most of the mouth rinses that are out there on the market today are divided into two categories, those that contain fluoride and those that are antiseptic. The ones that contain fluoride are really addressing cavities, and some people should, that\u2019s what they need, because they have a high caries risk and rate. But most patients, and remember, over 50 percent of the population is suffering from active gum disease, and that\u2019s young adults. Those are 35 and over. When you start getting to the numbers of the 60s and the 70s, those numbers are heading up to 75, 80 percent, okay? And that\u2019s significant gum disease. It\u2019s not simple. superficial inflammation. That means there\u2019s been some bone loss.<\/p>\n<p style=\"font-weight: 400;\">So we helped design a mouth rinse, which is based on botanical ingredients. What it does is it does reduce the bacterial population and shift it to a healthier population, and it does engage the inflammatory system and actually down regulates the active inflammation and sort of reset that inflammation so you\u2019re going to have less destruction. And at the same time, it actually activates the repair mechanism so that we can actually rebuild that tissue, heal that tissue, make it more robust and healthy. It goes back to a healthy lifestyle. Tissue that\u2019s more healthy and stronger and denser collagen and better organization of the vascular channels and all the positive aspects that we\u2019d like to see in healthy, vibrant tissue is more able to resist destruction, resist periodontal disease, and respond appropriately to it effectively. So that\u2019s why we, that mouthwash is a big asset, and in our practice, that\u2019s our go to product. So going back to what we use, we\u2019d recommend a, excuse the pun, but a steady diet of twice a day brushing, flossing, or some interdental cleaning and PeriActive mouthwash.<\/p>\n<p style=\"font-weight: 400;\"><strong>Chris Kresser:\u00a0 <\/strong>And can that be used even when there is already mild gum disease present? Is it both a preventative and something that can help with treatment?<\/p>\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\"><p>Your gums may hold the key to whole-body health. In this episode, Dr. William Levine reveals how oral inflammation drives chronic disease\u2014and explores cutting-edge treatments like lasers, PRP, and PEMF. #chriskresser #revolutionhealthradio <\/p><\/blockquote>\n<p style=\"font-weight: 400;\"><strong>Bill Levine:\u00a0 <\/strong>It\u2019s actually a great question, and I\u2019m going to answer it in a bit of an elliptical way. I want to dial back to what we described. Remember that pocket that we described, filled with bacteria and inflammatory activity. PeriActive works by penetrating directly through the gums. So we\u2019ve actually measured what we call inflammatory biomarkers inside that pocket and we see that if you use PeriActive, you will have a big drop in the inflammatory biomarkers. So it will actually change the bacterial population, even inside the pocket. So yes, it\u2019s good as a therapeutic, it\u2019s great as a preventive, and it\u2019s important to use.<\/p>\n<h2>Emerging Technologies in Periodontal Care<\/h2>\n<p style=\"font-weight: 400;\"><strong>Chris Kresser:\u00a0 <\/strong>Excellent. So when you think about the future of oral care and periodontal health, what are some of the things that are exciting for you, that are new developments, new treatments, things that you think will move us forward to the next generation of oral care?<\/p>\n<p style=\"font-weight: 400;\"><strong>Bill Levine:\u00a0 <\/strong>I would say two new technologies that we\u2019re using actively in the office now are actually fascinating. One is the technology we\u2019re using. We\u2019ve extended and expanded our laser team, and we\u2019re using different lasers. Some are lasers that are active in killing bacteria without using chemicals, and that\u2019s terrific, and others are active in actually removing the hardened bacteria, the calculus and the inflamed tissue from the area, and that\u2019s a second step. So by using those different types of lasers, we\u2019re actually reducing the amount of periodontal surgery that we\u2019re needing, and it\u2019s incentivizing people to continue treatment and to stay compliant. Another interesting thing is really not for preventive care, but it\u2019s a technology that has been worked on now for a very long time, for 25 years or so, but it\u2019s really now come to the fore because, and it\u2019s so logical. What we do is before we do something like an extraction or a specific type of treatment that we would need tissue repair on, we take the blood from the patient, we actually centrifuge it out, and take out from them the healing elements that are normally active in your bloodstream, but we don\u2019t have, the bloodstream, they\u2019re very dilute because you don\u2019t need them. But on the other hand, we know we\u2019re going to need it, so we take them out and we place them right into the area. We actually have sped [up] the process of healing of both bone and tissue. So that\u2019s been a lot of fun as well.<\/p>\n<p style=\"font-weight: 400;\">I think downstream, we\u2019re going to do what you were describing earlier. As our increase in knowledge of AI increases, what we\u2019re going to see is a very clear analysis of the bacterial population, the inflammatory mediators, and a personalized analysis of your risk factors, what steps need to be taken care of. But I see that about a decade from now, because it\u2019s going to take a little time to actually organize what data we need, how we use the AI algorithms to analyze that, and when the data comes out, developing a universal system that, because it can\u2019t be a customized, personalized system. Because we have to build a, it has to be a personalized program, but not a personalized system. So that diagnosis is going to lead to an enormous amount of specificity in the treatment. In other words, how often should we visit the hygienist after we\u2019ve stabilized your disease? Well, you may have a low risk profile. I may not need to see for six months. On the other hand, you may have a high risk factor, and you may need to be seen every two months. Well, these are important things to know and that so I think that\u2019s downstream, and it\u2019s not far away with the progress in medicine today.<\/p>\n<p style=\"font-weight: 400;\"><strong>Chris Kresser:\u00a0 <\/strong>I\u2019m glad you brought up laser and PRP. I just had a PRP shot in my foot for plantar fasciitis, and I\u2019ve used PRP in other contexts, and I found it to be a pretty incredible healing modality. What about infrared light? I\u2019ve seen some papers recently about red light therapy and some, even some consumer devices where there\u2019s like a tray, a dental appliance you can put in your mouth that emits red light. What do you think about the research on that?<\/p>\n<p style=\"font-weight: 400;\"><strong>Bill Levine:\u00a0 <\/strong>The infrared light is actually part of what we call the diode system of lasers. Because the diode system of lasers has two unusual effects. One of them is that it\u2019s great as an antibacterial because it\u2019s absorbed by chromophobes, which means that the bacteria are absorbing them. It\u2019s killing bacteria. And if you don\u2019t use a high frequency or a high energy level, Y watts, you\u2019re actually dealing with a very, relatively non dangerous instrument that if used carefully with special safety goggles, because that\u2019s critical, absolutely critical, because it can damage your eyes, and then you can actually do great things with it. And now it\u2019s not using a drug, so there\u2019s no resistance. There\u2019s another factor, though, in the diode lasers, if used at low frequencies. The diode lasers that do something called photobiomodulation, or PBM, and PBM actually can stimulate the body to really respond and heal on its own. So you\u2019re both reducing the insult and stimulating the body to repair. And that\u2019s an area that\u2019s really now just gaining traction in dentistry and in the world. And it\u2019s, in a sense, because PBM, or the biomodulation, is something that was really hard for us to believe. But it\u2019s there, and clinically we\u2019re seeing it, the data is not as strong as the clinical reality. And it\u2019s like the guy saying, well, I know the data isn\u2019t supported, but my gosh, it\u2019s been helping my patients tremendously. So we use a lot of that.<\/p>\n<p style=\"font-weight: 400;\"><strong>Chris Kresser:\u00a0 <\/strong>Lack of evidence is not always evidence against. Sometimes.<\/p>\n<p style=\"font-weight: 400;\"><strong>Bill Levine:\u00a0 <\/strong>Correct, absolutely. So be open minded, but careful. What did Obama say? Trust but verify?<\/p>\n<p style=\"font-weight: 400;\"><strong>Chris Kresser:\u00a0 <\/strong>Something like that. Yeah, yeah. And, then for me as a clinician, when I think about it, the other element is, what is the risk? If the risk is low, but the upside, or in some cases, almost non-existent, but there\u2019s significant upside, then I\u2019m more willing to give that a shot with something that\u2019s less proven. If it\u2019s an unknown risk or high risk, then I\u2019m going to be a lot more concerned.<\/p>\n<p style=\"font-weight: 400;\"><strong>Bill Levine:\u00a0 <\/strong>I can\u2019t agree with you more, yeah.<\/p>\n<h2>The Future of Frequency Medicine and Personalized Care<\/h2>\n<p style=\"font-weight: 400;\"><strong>Chris Kresser:\u00a0 <\/strong>Along these same lines, just exploring newer treatments, have you seen any of the literature on post electromagnetic field therapy or PEMF? In researching for this show, I saw some papers about PEMF improving the stability of periodontal implants, I saw a paper on PEMF, possibly helping in the context of periodontitis, and I\u2019ve used it myself and recommended it for musculoskeletal issues and other issues where my understanding of it is that it improves microcirculation in the capillary bed, and promotes blood flow. So I\u2019m just curious about that, because that\u2019s another treatment that I\u2019ve found to be pretty low risk in most cases, but sometimes high reward.<\/p>\n<p style=\"font-weight: 400;\"><strong>Bill Levine:\u00a0 <\/strong>So I\u2019m going to answer this on two levels, because actually, I have a deep knowledge of that whole area, but it\u2019s not really used much in dentistry, and I\u2019ll explain to you the flaw in it. I actually am, but I\u2019m going to start off by telling you, that is the future. The future of medicine is frequency medicine. There\u2019s no question about it, and it works. But the problem behind frequency medicine is the way you are able to measure frequencies is not yet, does not yet enable us to actually get precise diagnostic measures as to what frequency you need to apply in order to get the therapeutic response that you want. And we\u2019re actually working on that as a separate scientific project in a different company. But the concept is, if we can make more precise diagnosis and assessments of exactly what the frequency that we need is to accomplish a certain biologic task, we can actually not only diagnose it more effectively, we can actually change the process. And we\u2019re seeing some fantastic stuff coming out of our lab, and it\u2019s mind blowing. But it\u2019s no question you touched on what I think is going to be the biggest game changer. I think it\u2019s going to do, frankly, for the healthcare system, what computers did for the world. I mean, computers changed our lives. Health care is going to change. The health care that you see now, in a decade, is going to be completely different.<\/p>\n<p style=\"font-weight: 400;\"><strong>Chris Kresser:\u00a0 <\/strong>I\u2019m excited to hear a little more about that, if you have a few more minutes, because this is also an area of interest of mine. What has led to that belief for you? What do you think it will address?<\/p>\n<p style=\"font-weight: 400;\"><strong>Bill Levine:<\/strong>\u00a0 There is data that EMF, different frequencies of EMF, can actually do and make significant physiologic changes. At the same time, it\u2019s not predictable. And the reason it\u2019s not predictable is we\u2019re not sure what frequency is correct, because the frequency is customized by the person\u2019s personal status and the amount of noise is clouding the frequency reading. We\u2019re really off topic here, but it\u2019s okay.<\/p>\n<p style=\"font-weight: 400;\"><strong>Chris Kresser: <\/strong>\u00a0Yeah, we like to go in different directions here. I mean, it\u2019s still connected to dental health, maybe not yet, but as you\u2019re saying, it very well may be in a few years.<\/p>\n<p style=\"font-weight: 400;\"><strong>Bill Levine:<\/strong>\u00a0 We\u2019re looking at diabetes now, okay? And in our preliminary studies, we were actually able, with this technology, to actually diagnose changes in diabetic responses, hyper and hypoglycemia, 15 minutes before they occurred. That is so early that actually the patient doesn\u2019t even feel anything. The patient feels absolutely fine. We can tell them in 15 minutes you are going to have a severe hypoglycemic event. You need to drink some juice or have a candy, whatever it is. You need some sugar. We actually have shown in an early stage trial that we can actually reverse that effect, in a sense, and reduce the need for insulin using frequencies that we apply to the patient. So these things are groundbreaking. Imagine the life of a diabetic without needles, without invasive treatment, and on a much more stable level, with just a simple wearable wristwatch. That\u2019s where we\u2019re going.<\/p>\n<p style=\"font-weight: 400;\"><strong>Chris Kresser:<\/strong>\u00a0 That\u2019s incredible. Yeah, that\u2019s very exciting, and I look forward to that day, because there are certain areas of medicine that I feel are ripe for this kind of innovation and disruption, where the treatments have been largely the same for the past 50, 60, years or more. So very exciting to hear that you\u2019re working on this. So Bill, before we finish up, where can people learn more about Periactive oral rinse? It sounds like a phenomenal product.<\/p>\n<p style=\"font-weight: 400;\"><strong>Bill Levine:<\/strong>\u00a0 I would encourage you to go on the website, read about it, and you can contact us if you need. The website is <a href=\"http:\/\/getperiactive.com\/\" target=\"_blank\" rel=\"noopener\">GetPeriactive.com<\/a> and the product actually has changed the way our patients feel about periodontal disease and how they respond. So it\u2019s been great for our practice. It\u2019s been great for our patients, and I\u2019m pleased to have been involved in development. It\u2019s one of my issues that I actually take a lot of pride in.<\/p>\n<p style=\"font-weight: 400;\"><strong>Chris Kresser:<\/strong>\u00a0 Yeah, fantastic. Well, thanks again, Bill for your time. A fascinating conversation. I\u2019m sure everyone has enjoyed it.<\/p>\n<p style=\"font-weight: 400;\"><strong>Bill Levine:<\/strong>\u00a0 Sorry for digressing at the end, I couldn\u2019t resist.<\/p>\n<p style=\"font-weight: 400;\"><strong>Chris Kresser:\u00a0 <\/strong>Not at all. No. I took you there because the listeners of this show are very interested in the cutting edge therapies and treatments that are being developed, especially ones that are non-invasive and low risk, and that work with the body\u2019s physiology instead of against it. And I think if there\u2019s one kind of general thing we could say about all of the three of the forward looking treatments you\u2019re talking about, whether it\u2019s PRP or photobiomodulation or PEMF, that\u2019s what they\u2019re doing, right? They\u2019re working with the body\u2019s physiology and improving the function of the body instead of suppressing, just suppressing the symptoms with drugs..<\/p>\n<p style=\"font-weight: 400;\"><strong>Bill Levine:<\/strong>\u00a0 Yeah. Interestingly, just to digress again, but one of the biggest changes in cancer therapy has been the ability to use the person\u2019s natural immune system to actually fight the cancer, instead of, or certainly supplementing the chemotherapy drugs that we standardly use. It\u2019s an approach that is so logical, you sort of wonder why we didn\u2019t think of it earlier. Well, we actually wanted to do it earlier. We didn\u2019t have the capabilities of doing it earlier. But now that it\u2019s hitting the CAR-T and all the others, this is saving a lot of lives.<\/p>\n<p style=\"font-weight: 400;\"><strong>Chris Kresser:<\/strong>\u00a0 Absolutely. Well, thanks again, Bill, and thanks everyone for listening. Keep sending your questions to <a href=\"https:\/\/chriskresser.com\/podcastquestion\" target=\"_blank\" rel=\"noopener\">ChrisKresser.com\/podcastquestion<\/a>. We\u2019ll talk to you next time.<\/p>\n<\/p><\/div>\n<p><script type=\"c912cff3271eacc776de6db8-text\/javascript\">\nsetTimeout(function(){ !function(f,b,e,v,n,t,s){if(f.fbq)return;n=f.fbq=function(){n.callMethod?\nn.callMethod.apply(n,arguments):n.queue.push(arguments)};if(!f._fbq)f._fbq=n;\nn.push=n;n.loaded=!0;n.version='2.0';n.queue=[];t=b.createElement(e);t.async=!0;\nt.src=v;s=b.getElementsByTagName(e)[0];s.parentNode.insertBefore(t,s)}(window,\ndocument,'script','https:\/\/connect.facebook.net\/en_US\/fbevents.js');\nfbq('init', '162088684321454', {\n});\nfbq('track', 'PageView');\n}, 3000);\n<\/script><br \/>\n<br \/><\/p>\n","protected":false},"excerpt":{"rendered":"<p>In this episode, we discuss: How periodontal disease develops and impacts the body Recognizing symptoms of periodontal disease Conventional and modern treatments for standard chronic periodontal disease How to prevent gum disease Emerging technologies in periodontal care The future of frequency medicine and personalized care Show notes: Hey everyone, Chris Kresser here. Welcome to another [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":21713,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[149196,115426,122115,149197,149198,149199,149200,12386,149201,149202],"tags":[18455,50732,2561,14365,3229,5091],"dealstore":[],"offerexpiration":[],"class_list":["post-321869","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-chris-kresser","category-dentistry","category-functional-medicine","category-gum-disease","category-oral-care","category-oral-health","category-periodontal-disease","category-podcast","category-revolution-health-radio","category-rhr-podcast","tag-inflammation","tag-levine","tag-oral","tag-rhr","tag-science","tag-william"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.4 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>RHR: The Science Behind Oral Inflammation, with Dr. William Levine - Som2ny Network<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/fivemor.com\/?p=321869\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"RHR: The Science Behind Oral Inflammation, with Dr. William Levine - Som2ny Network\" \/>\n<meta property=\"og:description\" content=\"In this episode, we discuss: How periodontal disease develops and impacts the body Recognizing symptoms of periodontal disease Conventional and modern treatments for standard chronic periodontal disease How to prevent gum disease Emerging technologies in periodontal care The future of frequency medicine and personalized care Show notes: Hey everyone, Chris Kresser here. 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