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Rachel Reeves<\/a> is preparing to unveil billions of pounds worth of cuts across Whitehall in her make-or-break spending review.<\/p>\n<\/div>\n Analysis by the House of Commons library suggests unprotected departments will see their budgets slashed by \u00a35 billion in real terms as the chancellor tries to pay for increased spending on the NHS and defence.<\/p>\n<\/div>\n The Home Office is expected to be one of the biggest losers, with its overall budget facing a real terms cut of nearly \u00a3500 million, despite warnings from police chiefs that it will harm their attempts to tackle crime.<\/p>\n<\/div>\n Angela Rayner\u2019s<\/a> ministry of housing, communities and local government could also lose around \u00a3350 million, putting at risk Labour\u2019s pre-election pledge to build 1.5 million new homes before the next election.<\/p>\n<\/div>\n The budget for adult education and apprenticeships could also face real terms cuts worth over \u00a3685 million by 2028-29.<\/p>\n<\/div>\n Both Rayner and home secretary Yvette Cooper<\/a> were the last cabinet ministers to have their budgets agreed \u2013 with Reeves eventually taking the highly unusual step of imposing a settlement on the Home Office.<\/p>\n<\/div>\n The chancellor will on Wednesday announce a huge increase in so-called \u201ccapital\u201d spending on major infrastructure projects, including \u00a315.6 billion on transport projects<\/a> in the north and Midlands, and \u00a315 billion on the new Sizewell C nuclear plant<\/a>.<\/p>\n<\/div>\n She will also say the government will spend \u00a386 billion on the science and technology sector by the next election, to help fund research into drug treatments and longer-lasting batteries.<\/p>\n<\/div>\n