{"id":251518,"date":"2025-05-22T03:53:14","date_gmt":"2025-05-22T03:53:14","guid":{"rendered":"https:\/\/peraltafinancing.com\/agriculture\/all-g-unveils-tech-breakthrough-to-disrupt-infant-nutrition-market\/"},"modified":"2025-05-22T03:53:14","modified_gmt":"2025-05-22T03:53:14","slug":"all-g-unveils-tech-breakthrough-to-disrupt-infant-nutrition-market","status":"publish","type":"post","link":"https:\/\/fivemor.com\/?p=251518","title":{"rendered":"All G unveils tech breakthrough to disrupt infant nutrition market"},"content":{"rendered":"<p> <br \/>\n<\/p>\n<div>\n<p>Sydney-based <a href=\"https:\/\/www.allgfoods.com\/\">All G<\/a> claims it is forging a pathway to bring infant formula \u201cdramatically closer to the nutritional gold standard of human milk\u201d with breakthrough tech that forms human casein proteins into micelles, which are critical to the nutritional and functional benefits of breastmilk.<\/p>\n<p>The startup, which <a href=\"https:\/\/agfundernews.com\/australian-precision-fermentation-startup-all-g-plans-bovine-lactoferrin-launch-in-2025\">plans to bring bovine lactoferrin to the market later this year<\/a> followed by human lactoferrin in early 2026, has just filed a patent application for a formulation that includes five major human breast milk proteins made via precision fermentation: alpha-lactalbumin, lactoferrin, beta-casein, kappa-casein and serum albumin.<\/p>\n<p>It is now talking to \u201cmultiple global infant formula companies\u201d looking to develop products that more closely replicate human breast milk, said CEO Jan Pacas.<\/p>\n<p>\u201cThis is the closest infant formula has ever come to the real thing,\u201d added Pacas, who cofounded Australia\u2019s largest online pet care marketplace <a href=\"https:\/\/www.madpaws.com.au\/\">Mad Paws<\/a> (which went public in 2021) and HR software startup <a href=\"https:\/\/www.flarehr.com\/\">Flare<\/a>\u00a0(<a href=\"https:\/\/www.afr.com\/companies\/financial-services\/myob-buys-flare-in-big-shift-into-financial-services-20220913-p5bhnj\">sold to MYOB in 2022<\/a>) before creating All G in late 2020.<\/p>\n<p>He was joined the following year by Dr. Jared Raynes, a molecular biologist who first started working on producing <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2590152424000011\">phosphorylated beta casein proteins<\/a> via microbial fermentation a decade ago at Australia\u2019s national agency\u00a0<a href=\"https:\/\/www.csiro.au\/en\/\">CSIRO<\/a>.<\/p>\n<h4><strong>\u2018No one else has been able to manufacture human casein micelles\u2019<\/strong><\/h4>\n<p>Raynes told <em>AgFunderNews<\/em>: \u201cNo one else has been able to manufacture human casein micelles. Most infant formulas today rely on bovine casein micelles, which are structurally and functionally different from those in human milk. Bovine caseins are larger, form firmer curds in the infant stomach, and are associated with slower digestion.<\/p>\n<p>\u201cIn contrast, human caseins are softer, smaller and support steady nutrient release and more efficient absorption, better aligned with infant digestion and gut development.\u201d This difference matters nutritionally, he claimed, \u201cas it impacts how effectively nutrients are delivered during a critical window of growth.\u201d<\/p>\n<p>Without the micelle, which is critical for the delivery of calcium, phosphate, and other bioactive components, \u201cthe value of casein proteins is limited,\u201d he said.<\/p>\n<figure id=\"attachment_44928\" aria-describedby=\"caption-attachment-44928\" style=\"width: 1050px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-44928\" src=\"https:\/\/agfundernews.com\/wp-content\/uploads\/2025\/05\/All-G-lab.jpg\" alt=\"All G lab\" width=\"1050\" height=\"591\" srcset=\"https:\/\/agfundernews.com\/wp-content\/uploads\/2025\/05\/All-G-lab.jpg 1050w, https:\/\/agfundernews.com\/wp-content\/uploads\/2025\/05\/All-G-lab-300x169.jpg 300w, https:\/\/agfundernews.com\/wp-content\/uploads\/2025\/05\/All-G-lab-1024x576.jpg 1024w, https:\/\/agfundernews.com\/wp-content\/uploads\/2025\/05\/All-G-lab-768x432.jpg 768w\" sizes=\"auto, (max-width: 1050px) 100vw, 1050px\"\/><figcaption id=\"caption-attachment-44928\" class=\"wp-caption-text\">The All G lab in Sydney, Australia. \u201cOne of the things that really differentiates us is this foundational recombinant casein phosphorylation work,\u201d says CSO Dr. Jared Raynes. \u201cWe\u2019ve also proven that you can produce a stable casein micelle with just one casein protein, which was thought to be impossible.\u201d Image credit: All G<\/figcaption><\/figure>\n<h4><strong>\u2018Interest from multiple global formula companies\u2019<\/strong><\/h4>\n<p>Most infant formula contains a base of carbohydrates, proteins (typically from cow\u2019s milk but also from soy protein isolate), vegetable oils, vitamins and minerals. More premium products are also supplemented with nutrients such as synbiotics, lactoferrin, alpha-lactalbumin, MFGM, and OPOs.<\/p>\n<p>In recent years, several manufacturers have also started to add human milk oligosaccharides (HMOS) such as 2\u2019FL and LNnT made via precision fermentation, while some startups such as [the now defunct] <a href=\"https:\/\/agfundernews.com\/biomilq-files-for-bankruptcy-amid-ip-dispute-that-made-it-uninvestable-and-unacquirable\">Biomilq<\/a> have used mammary epithelial cells to make rarer HMOs and other nutrients in breast milk such as osteopontin and exosomes.<\/p>\n<p>Precision fermentation startup <a href=\"https:\/\/agfundernews.com\/helaina-raises-45m-series-b-as-human-lactoferrin-hits-the-market\">Helaina now offers human lactoferrin<\/a> for the adult nutrition segment with a view to moving into the more heavily regulated infant formula market, while <a href=\"https:\/\/agfundernews.com\/better-dairy-targets-high-margin-nutrition-market-with-precision-fermented-osteopontin\">Better Dairy has developed tech<\/a> to produce osteopontin via yeast fermentation.<\/p>\n<p>However, human casein micelles \u201chave never been produced at scale and assembling them into a micelle structure was technically out of reach,\u201d claimed Raynes, who noted that electrophoresis analysis shows that All G\u2019s five-protein formulation closely mirrors the protein profile of human breast milk.<\/p>\n<p>\u201cThis achievement offers a pathway to bring infant formula dramatically closer to the nutritional gold standard of human milk.\u201d<\/p>\n<p>He added: \u201cOur focus is on B2B sales and we\u2019ve already had interest from multiple global formula companies. Ultimately, we want to have impact at the global level and improve the quality of nutrition for as many infants as possible. Partnering with others is the best way to achieve that as quickly as possible.\u201d<\/p>\n<p>In the medium-term, All G plans to conduct clinical trials to \u201cdemonstrate the enhanced health benefits of its human milk protein ingredients,\u201d says the firm.<\/p>\n<figure id=\"attachment_44937\" aria-describedby=\"caption-attachment-44937\" style=\"width: 847px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-44937\" src=\"https:\/\/agfundernews.com\/wp-content\/uploads\/2025\/05\/All-G.png\" alt=\"An \u2018electrophoresis gel\u2019 demonstrates the similar composition of All G\u2019s human milk formulation compared to human breast milk. Image credit: All G\" width=\"847\" height=\"778\" srcset=\"https:\/\/agfundernews.com\/wp-content\/uploads\/2025\/05\/All-G.png 847w, https:\/\/agfundernews.com\/wp-content\/uploads\/2025\/05\/All-G-300x276.png 300w, https:\/\/agfundernews.com\/wp-content\/uploads\/2025\/05\/All-G-768x705.png 768w\" sizes=\"auto, (max-width: 847px) 100vw, 847px\"\/><figcaption id=\"caption-attachment-44937\" class=\"wp-caption-text\">An \u2018electrophoresis gel\u2019 demonstrates the similar composition of All G\u2019s human milk formulation compared to human breast milk. Image credit: All G<\/figcaption><\/figure>\n<h4><strong>Manufacturing and scaleup<\/strong><\/h4>\n<p>As for scalability, said Raynes, \u201cOur strains are already cost-effective for human lactoferrin and human caseins. We have multiple commercial partnerships lined up covering major Asian markets, Europe, and the US. We expect to be in commercial scale bioreactors (around 50kl \u2013 100kl) by Q4 this year.<\/p>\n<p>\u201cWe have already secured self-GRAS status for our bovine lactoferrin in the US and will be submitting to the FDA in the very near future. The landscape for approvals for human proteins is more complicated, but we are confident we have an approach that aligns with our launch and scale-up plan.\u201d<\/p>\n<p>An iron-binding anti-microbial protein found in mammalian milk, lactoferrin has\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9818722\/\">benefits<\/a> around immunity, iron regulation, digestive health, endurance, and skin health, but has historically only been available in small quantities owing to the costs and challenges of isolating it from milk (thousands of liters are required to make a single kilo).<\/p>\n<p>By producing lactoferrin in fermentation tanks using genetically engineered microbes All G and others in this space are seeking to unlock new markets.<\/p>\n<p>According to Raynes, \u201cWe\u2019ve had conversations with big players and they said, if you can give us this price, we will start putting it in yogurts and other mainstream applications, which they just can\u2019t at the moment with current prices. And we\u2019re going to be able to achieve prices where they say, Okay, we could really open the market for lactoferrin.\u201d<\/p>\n<\/p><\/div>\n\n","protected":false},"excerpt":{"rendered":"<p>Sydney-based All G claims it is forging a pathway to bring infant formula \u201cdramatically closer to the nutritional gold standard of human milk\u201d with breakthrough tech that forms human casein proteins into micelles, which are critical to the nutritional and functional benefits of breastmilk. The startup, which plans to bring bovine lactoferrin to the market [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":251519,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[12026],"tags":[20030,16557,8865,11209,13852,70797,5107,12884],"dealstore":[],"offerexpiration":[],"class_list":["post-251518","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-agriculture","tag-breakthrough","tag-disrupt","tag-infant","tag-market","tag-nutrition","tag-precision-fermentation","tag-tech","tag-unveils"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.4 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>All G unveils tech breakthrough to disrupt infant nutrition market - Som2ny Network<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/fivemor.com\/?p=251518\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"All G unveils tech breakthrough to disrupt infant nutrition market - Som2ny Network\" \/>\n<meta property=\"og:description\" content=\"Sydney-based All G claims it is forging a pathway to bring infant formula \u201cdramatically closer to the nutritional gold standard of human milk\u201d with breakthrough tech that forms human casein proteins into micelles, which are critical to the nutritional and functional benefits of breastmilk. 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